PMID- 32184155
OWN - NLM
STAT- MEDLINE
DCOM- 20210505
LR  - 20210505
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 387
DP  - 2020 Jun 1
TI  - Hippocampal cognitive impairment in juvenile rats after repeated mild traumatic 
      brain injury.
PG  - 112585
LID - S0166-4328(20)30284-9 [pii]
LID - 10.1016/j.bbr.2020.112585 [doi]
AB  - There is growing awareness that repeated mild traumatic brain injury (r-mTBI) can 
      cause deficits in learning and memory performance, however there is still a 
      paucity of preclinical data identifying the extent of these deficits. 
      Epidemiological data shows that juveniles are at high risk to sustain r-mTBI, and 
      these injuries may cause significant changes in cognitive abilities, as they 
      occur during a period where the brain is still maturing. This is particularly 
      true for the hippocampus, a brain region important for learning and memory 
      processes. R-mTBI during the juvenile period may disrupt functional capacity of 
      the hippocampus, and thus the normal development of cognitive processes 
      associated with this structure. To examine this issue we used a model of awake 
      closed head injury (ACHI) and administered 8 impacts over a 4 day period to 
      juvenile male and female rats (P25-28). A neurological assessment was preformed 
      after each impact, and anxiety and learning related behaviours were examined 1 
      and 7 days after the last impact. Our results indicate that r-mTBI was associated 
      with sensorimotor deficits in the acute phase immediately after each procedure. 
      R-mTBI also reduced the capacity for hippocampal-dependent learning for at least 
      7 days post-injury, but did not result in any long-lasting changes in 
      anxiety-related behaviours.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Pinar, Cristina
AU  - Pinar C
AD  - Division of Medical Sciences, University of Victoria, Victoria, British Columbia, 
      V8P 5C2, Canada.
FAU - Trivino-Paredes, Juan
AU  - Trivino-Paredes J
AD  - Division of Medical Sciences, University of Victoria, Victoria, British Columbia, 
      V8P 5C2, Canada.
FAU - Perreault, Samantha T
AU  - Perreault ST
AD  - Division of Medical Sciences, University of Victoria, Victoria, British Columbia, 
      V8P 5C2, Canada.
FAU - Christie, Brian R
AU  - Christie BR
AD  - Division of Medical Sciences, University of Victoria, Victoria, British Columbia, 
      V8P 5C2, Canada; Island Medical Program and Department of Cellular and 
      Physiological Sciences, University of British Columbia, Victoria, British 
      Columbia, V8P 5C2, Canada. Electronic address: brain64@uvic.ca.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200314
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Animals
MH  - Anxiety
MH  - Brain Concussion/complications/*psychology
MH  - Cognitive Dysfunction/etiology/*physiopathology
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - Learning
MH  - Male
MH  - Rats, Long-Evans
MH  - Spatial Memory
OTO - NOTNLM
OT  - Juvenile
OT  - Learning and memory
OT  - Sex differences
OT  - mTBI
COIS- Declaration of Competing Interest The authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2020/03/19 06:00
MHDA- 2021/05/06 06:00
CRDT- 2020/03/19 06:00
PHST- 2019/08/19 00:00 [received]
PHST- 2020/03/06 00:00 [revised]
PHST- 2020/03/06 00:00 [accepted]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/05/06 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
AID - S0166-4328(20)30284-9 [pii]
AID - 10.1016/j.bbr.2020.112585 [doi]
PST - ppublish
SO  - Behav Brain Res. 2020 Jun 1;387:112585. doi: 10.1016/j.bbr.2020.112585. Epub 2020 
      Mar 14.