PMID- 32184188
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20210215
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 213
DP  - 2020 Jun
TI  - Structural mediation of human brain activity revealed by white-matter 
      interpolation of fMRI.
PG  - 116718
LID - S1053-8119(20)30205-6 [pii]
LID - 10.1016/j.neuroimage.2020.116718 [doi]
AB  - Understanding how the anatomy of the human brain constrains and influences the 
      formation of large-scale functional networks remains a fundamental question in 
      neuroscience. Here, given measured brain activity in gray matter, we interpolate 
      these functional signals into the white matter on a structurally-informed 
      high-resolution voxel-level brain grid. The interpolated volumes reflect the 
      underlying anatomical information, revealing white matter structures that mediate 
      the interaction between temporally coherent gray matter regions. Functional 
      connectivity analyses of the interpolated volumes reveal an enriched picture of 
      the default mode network (DMN) and its subcomponents, including the different 
      white matter bundles that are implicated in their formation, thus extending 
      currently known spatial patterns that are limited within the gray matter only. 
      These subcomponents have distinct structure-function patterns, each of which are 
      differentially observed during tasks, demonstrating plausible structural 
      mechanisms for functional switching between task-positive and -negative 
      components. This work opens new avenues for the integration of brain structure 
      and function, and demonstrates the collective mediation of white matter pathways 
      across short and long-distance functional connections.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Tarun, Anjali
AU  - Tarun A
AD  - Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Geneva, 
      1202, Switzerland; Department of Radiology and Medical Informatics, University of 
      Geneva, Geneva, 1202, Switzerland. Electronic address: anjali.tarun@epfl.ch.
FAU - Behjat, Hamid
AU  - Behjat H
AD  - Center for Medical Image Science and Visualization, University of Linkoping, 
      Linkoping, 58183, Sweden.
FAU - Bolton, Thomas
AU  - Bolton T
AD  - Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Geneva, 
      1202, Switzerland; Department of Radiology and Medical Informatics, University of 
      Geneva, Geneva, 1202, Switzerland.
FAU - Abramian, David
AU  - Abramian D
AD  - Department of Biomedical Engineering, University of Linkoping, Linkoping, 58183, 
      Sweden; Department of Biomedical Engineering, Lund University, Lund, 22100, 
      Sweden.
FAU - Van De Ville, Dimitri
AU  - Van De Ville D
AD  - Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Geneva, 
      1202, Switzerland; Department of Radiology and Medical Informatics, University of 
      Geneva, Geneva, 1202, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200314
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Brain/*physiology
MH  - Connectome/*methods
MH  - Default Mode Network/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/methods
MH  - White Matter/*physiology
COIS- Declaration of competing interest The authors declare that they have no competing 
      financial interests.
EDAT- 2020/03/19 06:00
MHDA- 2021/02/16 06:00
CRDT- 2020/03/19 06:00
PHST- 2019/11/11 00:00 [received]
PHST- 2020/02/07 00:00 [revised]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
AID - S1053-8119(20)30205-6 [pii]
AID - 10.1016/j.neuroimage.2020.116718 [doi]
PST - ppublish
SO  - Neuroimage. 2020 Jun;213:116718. doi: 10.1016/j.neuroimage.2020.116718. Epub 2020 
      Mar 14.