PMID- 32184830
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2020
DP  - 2020
TI  - Oral Mesenchymal Stem/Progenitor Cells: The Immunomodulatory Masters.
PG  - 1327405
LID - 10.1155/2020/1327405 [doi]
LID - 1327405
AB  - Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue 
      engineering/regeneration for their multilineage differentiation potential and 
      easy acquisition. These cells encompass the periodontal ligament stem/progenitor 
      cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the 
      stem/progenitor cells from human exfoliated deciduous teeth (SHED), the gingival 
      mesenchymal stem/progenitor cells (GMSCs), the stem/progenitor cells from the 
      apical papilla (SCAP), the dental follicle stem/progenitor cells (DFSCs), the 
      bone marrow mesenchymal stem/progenitor cells (BM-MSCs) from the alveolar bone 
      proper, and the human periapical cyst-mesenchymal stem cells (hPCy-MSCs). Apart 
      from their remarkable regenerative potential, oral MSCs possess the capacity to 
      interact with an inflammatory microenvironment. Although inflammation might 
      affect the properties of oral MSCs, they could inversely exert a multitude of 
      immunological actions to the local inflammatory microenvironment. The present 
      review discusses the current understanding about the immunomodulatory role of 
      oral MSCs both in periodontitis and systemic diseases, their "double-edged sword" 
      uniqueness in inflammatory regulation, their affection of the immune system, and 
      the underlying mechanisms, involving oral MSC-derived extracellular vesicles.
CI  - Copyright (c) 2020 Li-li Zhou et al.
FAU - Zhou, Li-Li
AU  - Zhou LL
AD  - Department of Periodontology, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310009, China.
AD  - Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang 
      University School of Stomatology, China.
FAU - Liu, Wei
AU  - Liu W
AUID- ORCID: 0000-0001-9918-5022
AD  - Department of Periodontology, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310009, China.
AD  - Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang 
      University School of Stomatology, China.
FAU - Wu, Yan-Min
AU  - Wu YM
AD  - Department of Periodontology, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310009, China.
FAU - Sun, Wei-Lian
AU  - Sun WL
AD  - Department of Periodontology, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310009, China.
FAU - Dorfer, C E
AU  - Dorfer CE
AD  - Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, 
      Christian-Albrechts-Universitat zu Kiel, Kiel 24105, Germany.
FAU - Fawzy El-Sayed, K M
AU  - Fawzy El-Sayed KM
AUID- ORCID: 0000-0002-6261-3609
AD  - Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, 
      Cairo University, Cairo 11435, Egypt.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200225
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC7060886
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this article.
EDAT- 2020/03/19 06:00
MHDA- 2020/03/19 06:01
PMCR- 2020/02/25
CRDT- 2020/03/19 06:00
PHST- 2019/10/02 00:00 [received]
PHST- 2020/01/08 00:00 [revised]
PHST- 2020/01/13 00:00 [accepted]
PHST- 2020/03/19 06:00 [entrez]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2020/03/19 06:01 [medline]
PHST- 2020/02/25 00:00 [pmc-release]
AID - 10.1155/2020/1327405 [doi]
PST - epublish
SO  - Stem Cells Int. 2020 Feb 25;2020:1327405. doi: 10.1155/2020/1327405. eCollection 
      2020.