PMID- 32185309
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2529-198X (Electronic)
IS  - 2529-198X (Linking)
VI  - 29
IP  - 2
DP  - 2018 Jun
TI  - Stress perfusion Cardiac Magnetic Resonance in Patients with Antiphospholipid 
      Syndrome.
PG  - 99-102
LID - 10.31138/mjr.29.2.99 [doi]
AB  - BACKGROUND: Antiphospholipid syndrome (APS) is characterized by the combination 
      of recurrent arterial and venous thrombotic events and detection of persistently 
      elevated antiphospholipid antibody titers in the serum or plasma. APS clinical 
      manifestations also include non-thrombotic complications from various organ 
      systems, mainly the CNS, kidneys, and heart. Cardiac manifestations of APS 
      include valvulopathy, myocardial infarction and angina (stable, unstable, and 
      Pritzmental angina). A previously published case series of cardiac magnetic 
      resonance (CMR) in patients with APS has revealed a high rate of asymptomatic 
      myocardial necrosis and scarring, but the prevalence of myocardial ischemia 
      identified as CMR perfusion defects prior to development of necrosis is unknown. 
      AIMS OF THE STUDY: To detect CMR imaging markers of myocardial ischemia in APS 
      patients without symptoms of cardiovascular disease (CVD). METHODS: We will scan 
      fifty APS patients without symptoms of CVD stress-perfusion CMR in a 1.5 Tesla 
      tomographer, after intravenous infusion of adenosine and gadolinium. In addition 
      to markers of cardiac anatomy and function, we will record imaging markers of 
      ischemia and scarring, namely perfusion defects (PDs), and late gadolinium 
      enhancement (LGE). We will perform parametrics using dedicated software in order 
      to derive each patient's myocardial perfusion reserve index (MPRI). Scans will be 
      reviewed independently by two experienced reviewers, with evaluation of inter- 
      and intra-observer reliability. Statistical hypotheses will be examined using 
      Student's test and Pearson's correlation coefficient, or non-parametric 
      equivalents (Kruskall-Wallis and Spearman) for continuous variables, and Fisher's 
      exact test for binary variables. Linear or logistic regression analyses will be 
      used to investigate APS-related determinants of subclinical myocardial ischemia. 
      ANTICIPATED BENEFITS: We expect to identify CMR imaging patterns characteristic 
      of APS, which will allow proactive therapeutic interventions for primary 
      prevention of CVD and guide further research into the pathogenesis of APS cardiac 
      manifestations.
CI  - (c) 2018 The Mediterranean Journal of Rheumatology (MJR).
FAU - Tektonidou, Maria G
AU  - Tektonidou MG
AD  - First Department of Propaedeutic and Internal Medicine, Joint Rheumatology 
      Program, Laikon Hospital, University of Athens Medical School, Athens, Greece.
FAU - Sfikakis, Petros P
AU  - Sfikakis PP
AD  - First Department of Propaedeutic and Internal Medicine, Joint Rheumatology 
      Program, Laikon Hospital, University of Athens Medical School, Athens, Greece.
FAU - Kolovou, Genovefa
AU  - Kolovou G
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Mavrogeni, Sophie
AU  - Mavrogeni S
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20180629
PL  - Greece
TA  - Mediterr J Rheumatol
JT  - Mediterranean journal of rheumatology
JID - 101730166
PMC - PMC7046068
OTO - NOTNLM
OT  - antiphospholipid syndrome
OT  - cardiac Magnetic Resonance
OT  - heart disease
OT  - stress perfusion cardiac magnetic resonance
EDAT- 2018/06/29 00:00
MHDA- 2018/06/29 00:01
PMCR- 2018/06/29
CRDT- 2020/03/19 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/04/19 00:00 [accepted]
PHST- 2020/03/19 06:00 [entrez]
PHST- 2018/06/29 00:00 [pubmed]
PHST- 2018/06/29 00:01 [medline]
PHST- 2018/06/29 00:00 [pmc-release]
AID - MJR-29-2-99 [pii]
AID - 10.31138/mjr.29.2.99 [doi]
PST - epublish
SO  - Mediterr J Rheumatol. 2018 Jun 29;29(2):99-102. doi: 10.31138/mjr.29.2.99. 
      eCollection 2018 Jun.