PMID- 32185401
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1869-1447 (Electronic)
IS  - 1869-1439 (Linking)
VI  - 31
IP  - 2
DP  - 2021 Jun
TI  - Absence of T1 Hyperintensity in the Brain of High-risk Patients After Multiple 
      Administrations of High-dose Gadobutrol for Cardiac Magnetic Resonance.
PG  - 347-355
LID - 10.1007/s00062-020-00897-z [doi]
AB  - PURPOSE: A prospective study was conducted to evaluate signal changes in the 
      dentate nucleus, globus pallidus, pons, and thalamus (normalized to the deep 
      cerebellum white matter) in T1-weighted magnetic resonance (MR) images after 
      serial injections of gadobutrol in patients with thalassemia without neurological 
      lesions. METHODS: In this study three groups were scanned at both 1.5 T and 3 T: 
      15 thalassemia patients transfused and chelated with >/=4 gadobutrol 
      administrations at a high dose (0.2 mmol/kg per scan) for late gadolinium 
      enhancement (LGE) cardiovascular MR, 8 thalassemia patients and 13 healthy 
      subjects who had never received gadolinium-based contrast agents (GBCA). RESULTS: 
      Signal intensity (SI) ratios at 1.5 T in all regions were comparable among the 
      three groups and were not correlated with the number of gadobutrol 
      administrations. In healthy subjects SI ratios were significantly different among 
      the 4 regions, being higher in the pallidus. The SI ratios at 1.5 T were 
      significantly higher and not correlated with SI ratios at 3 T or with iron 
      overload in the same regions assessed by the T2* technique. CONCLUSION: This 
      article describes the lack of increased SI in T1-weighted MR images after 
      repeated administration of gadobutrol for cardiovascular MR studies in 
      a high-risk population (high dose per scan, iron overload that can facilitate the 
      transmetalation of gadolinium) scanned at 3 T and 1.5 T.
FAU - Meloni, Antonella
AU  - Meloni A
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - Montanaro, Domenico
AU  - Montanaro D
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - De Marchi, Daniele
AU  - De Marchi D
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - Resta, Mariachiara
AU  - Resta M
AD  - Istituto di Radiologia, Policlinico Universita di Bari, 11 Giulio Cesare Square, 
      70124, Bari, Italy.
FAU - Keilberg, Petra
AU  - Keilberg P
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - Pistoia, Laura
AU  - Pistoia L
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - Positano, Vincenzo
AU  - Positano V
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - Spasiano, Anna
AU  - Spasiano A
AD  - Unita Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda 
      Ospedaliera di Rilievo Nazionale "A. Cardarelli", 9 Cardarelli Street, 80131, 
      Napoli, Italy.
FAU - Casini, Tommaso
AU  - Casini T
AD  - Centro Talassemie ed Emoglobinopatie, Ospedale "Meyer", 13 Luca Giordano Street, 
      50132, Firenze, Italy.
FAU - De Bari, Caterina Cinzia
AU  - De Bari CC
AD  - Unita Operativa Immunoematologia e Medicina Trasfusionale, Ospedale "San Donato", 
      20 Pietro Nenni Street, 52100, Arezzo, Italy.
FAU - De Cori, Sara
AU  - De Cori S
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy.
FAU - Pepe, Alessia
AU  - Pepe A
AD  - MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. 
      Cataldo, 1 Moruzzi Street, 56124, Pisa, Italy. alessia.pepe@ftgm.it.
LA  - eng
PT  - Journal Article
DEP - 20200317
PL  - Germany
TA  - Clin Neuroradiol
JT  - Clinical neuroradiology
JID - 101526693
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
RN  - AU0V1LM3JT (Gadolinium)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Cerebellar Nuclei
MH  - *Contrast Media
MH  - Gadolinium
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Organometallic Compounds
MH  - Prospective Studies
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Brain
OT  - Cardiac magnetic resonance imaging
OT  - Gadolinium deposition
OT  - Signal intensity
OT  - Thalassemia
EDAT- 2020/03/19 06:00
MHDA- 2021/11/03 06:00
CRDT- 2020/03/19 06:00
PHST- 2019/10/01 00:00 [received]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
AID - 10.1007/s00062-020-00897-z [pii]
AID - 10.1007/s00062-020-00897-z [doi]
PST - ppublish
SO  - Clin Neuroradiol. 2021 Jun;31(2):347-355. doi: 10.1007/s00062-020-00897-z. Epub 
      2020 Mar 17.