PMID- 32185656
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 199
IP  - 1
DP  - 2021 Jan
TI  - Evaluating the Association Between Dental Fluorosis and Polymorphisms in Bone 
      Development and Mineralization Genes Among Population from a Fluoride Endemic 
      Region of Eastern India.
PG  - 1-8
LID - 10.1007/s12011-020-02116-9 [doi]
AB  - Close to 12 million people in India are affected by more than the desirable level 
      of fluoride in drinking water that could lead to dental, skeletal, and 
      non-skeletal fluorosis. Dental fluorosis is a developmental defect that results 
      in hypo-mineralization and pronounced porosity of enamel in the affected 
      individuals. As estrogen receptor 1 (ESR1), collagen type 1 alpha 2 (COL1A2), 
      bone gamma-carboxyglutamic acid protein (BGLAP), and secreted protein acidic and 
      cysteine rich (SPARC) genes are involved in bone development and mineralization, 
      polymorphisms in these genes could be determining factors in influencing the risk 
      to fluorosis among the exposed individuals in fluoride endemic areas. A 
      case-control study was carried out among a total of 87 individuals (case = 36, 
      control = 51) to examine the association between selected polymorphisms in the 
      ESR1, COL1A2, BGLAP, and SPARC genes and risk of dental fluorosis from a fluoride 
      endemic region of Eastern India. Altogether, 10 single nucleotide polymorphisms 
      (SNPs) in ESR1 (rs2234693, rs2228480, rs3798577, rs2077647, and rs9340799), 
      COL1A2 (rs42524, rs412777), BGLAP (rs1800247), and SPARC (rs6579885, rs4958278) 
      genes were genotyped through PCR-RFLP in these subjects. The association of the 
      SNPs for disease risk estimation was measured by odds ratio with 95% confidence 
      interval. The risk genotypes of none of the 10 SNPs showed statistically 
      significant association with risk of dental fluorosis. Frequencies of the 
      haplotypes in the intragenic SNPs of the ESR1, COL1A2, and SPARC genes did not 
      reveal any statistically significant difference between the case and control 
      groups. The present study is the first of its kind from India that has attempted 
      to investigate possible involvement of genetic factors in influencing the risk to 
      fluorosis among the population from a fluoride endemic region.
FAU - Saha, Depanwita
AU  - Saha D
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8, Sector-C, East Kolkata Township, Kolkata, 700107, India.
FAU - Goswami, Rakesh
AU  - Goswami R
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8, Sector-C, East Kolkata Township, Kolkata, 700107, India.
FAU - Majumdar, Kunal Kanti
AU  - Majumdar KK
AD  - Department of Community Medicine, KPC Medical College and Hospital, 1F Raja S. C. 
      Mullick Road, Jadavpur, Kolkata, 700032, India.
FAU - Sikdar, Nilabja
AU  - Sikdar N
AD  - Human Genetics Unit, Indian Statistical Institute, 203 B. T. Road, Baranagar, 
      Kolkata, 700108, India.
FAU - Pramanik, Sreemanta
AU  - Pramanik S
AUID- ORCID: 0000-0003-0448-2118
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8, Sector-C, East Kolkata Township, Kolkata, 700107, India. 
      sreemanta@gmail.com.
LA  - eng
GR  - BT/PR8283/MED/12/619/2013/Department of Biotechnology , Ministry of Science and 
      Technology/
PT  - Journal Article
DEP - 20200318
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - Bone Development
MH  - Case-Control Studies
MH  - *Fluorides
MH  - *Fluorosis, Dental/epidemiology/genetics
MH  - Humans
MH  - India/epidemiology
OTO - NOTNLM
OT  - Association
OT  - Candidate gene
OT  - Case-control
OT  - Dental fluorosis
OT  - Endemic
OT  - Polymorphism
EDAT- 2020/03/19 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/03/19 06:00
PHST- 2019/12/09 00:00 [received]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
AID - 10.1007/s12011-020-02116-9 [pii]
AID - 10.1007/s12011-020-02116-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2021 Jan;199(1):1-8. doi: 10.1007/s12011-020-02116-9. Epub 
      2020 Mar 18.