PMID- 32186231
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20210428
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 140
IP  - 7
DP  - 2020 Jul
TI  - EGFR cut-off point for prognostic impact in laryngeal squamous cell carcinoma.
PG  - 610-614
LID - 10.1080/00016489.2020.1738548 [doi]
AB  - Background: Various molecular biomarkers, including epidermal growth factor 
      receptor (EGFR), have gained importance as predictors of head and neck cancer 
      disease progression.Aims: This study aimed to investigate the ability of EGFR 
      expression as a prognostic marker for laryngeal squamous cell carcinoma 
      (LSCC).Materials and methods: A total of 31 patients with LSCC with 
      immunohistochemistry (IHC) staining for EGFR were examined. Digital image 
      processing was applied to analyze EGFR staining intensity and percent 
      distribution, which were calculated as the H-score. We used a receiver operating 
      characteristic (ROC) curve to identify the best cut-off point of EGFR expression, 
      with H-score separated into high- and low-grade for cancer recurrence 
      prediction.Results: The cut-off point of EGFR expression for high- and low-grades 
      was an H-score of 170 with a sensitivity of 75% and a specificity of 66.7%. Using 
      this cut-off, 14 (45.16%) and 17 (54.84%) patients were categorized as having 
      high- and low-grades EGFR, respectively. The analysis showed a significant 
      reverse correlation between the EGFR grade and LSCC recurrence (RR, 0.4; 95% CI, 
      0.17-0.98; p = .02).Conclusions: Our study demonstrated that EGFR grading using 
      H-score with the generated cut-off point by the ROC curve might be further 
      applied as a potential marker for LSCC prognostic prediction.
FAU - Leesutipornchai, Thiratest
AU  - Leesutipornchai T
AUID- ORCID: 0000-0001-8436-1142
AD  - Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Ratchataswan, Thanaporn
AU  - Ratchataswan T
AUID- ORCID: 0000-0002-9085-7272
AD  - Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Vivatvakin, Sarocha
AU  - Vivatvakin S
AUID- ORCID: 0000-0003-4453-2327
AD  - Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Ruangritchankul, Komkrit
AU  - Ruangritchankul K
AUID- ORCID: 0000-0003-2945-7760
AD  - Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Keelawat, Somboon
AU  - Keelawat S
AUID- ORCID: 0000-0002-4180-7914
AD  - Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Kerekhanjanarong, Virachai
AU  - Kerekhanjanarong V
AUID- ORCID: 0000-0003-0728-3595
AD  - Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
FAU - Bongsebandhu-Phubhakdi, Saknan
AU  - Bongsebandhu-Phubhakdi S
AUID- ORCID: 0000-0003-2357-3568
AD  - Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Mahattanasakul, Patnarin
AU  - Mahattanasakul P
AUID- ORCID: 0000-0001-6552-5463
AD  - Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
AD  - Department of Otolaryngology, Head and Neck Surgery, King Chulalongkorn Memorial 
      Hospital, Thai Red Cross Society, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20200318
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Analysis of Variance
MH  - Biomarkers/analysis
MH  - ErbB Receptors/analysis/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism
MH  - Prognosis
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Squamous Cell Carcinoma of Head and Neck/*metabolism
OTO - NOTNLM
OT  - EGFR
OT  - H-score
OT  - immunohistochemistry
OT  - laryngeal squamous cell carcinoma
OT  - prognostic factor
OT  - receiver operating characteristic curve
EDAT- 2020/03/19 06:00
MHDA- 2021/04/29 06:00
CRDT- 2020/03/19 06:00
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
AID - 10.1080/00016489.2020.1738548 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2020 Jul;140(7):610-614. doi: 10.1080/00016489.2020.1738548. 
      Epub 2020 Mar 18.