PMID- 32186757
OWN - NLM
STAT- MEDLINE
DCOM- 20210121
LR  - 20210121
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 45
IP  - 6
DP  - 2020 Jun
TI  - Association between oxidative stress biomarkers and PON and GST polymorphisms as 
      a predictor for susceptibility to the effects of pesticides.
PG  - 1951-1959
LID - 10.3892/ijmm.2020.4541 [doi]
AB  - Low levels of pesticides persist in the environment and can affect the health of 
      exposed subjects. Oxidative stress is considered as one of the mechanisms 
      responsible for the adverse effects on human health and some molecules may 
      represent useful biomarkers for the evaluation of this physiological balance. 
      This study investigated the role of these biomarkers, such as advanced oxidation 
      protein products (AOPP), advanced glycation end‑products (AGE) and reactive 
      oxygen metabolites (ROMs) in relation to genetic polymorphisms of paraoxonase 
      (PON)1, PON2, glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase 
      theta 1 (GSTT1) and glutathione S‑transferase mu 1 (GSTM1). An increase in the 
      levels of these biomarkers is usually inversely associated with the depletion of 
      the biological antioxidant potential (BAP). The results revealed a statistically 
      significant difference in the sex‑dependent variation of AGE, BAP, AOPP and ROM 
      protein levels. Furthermore, an association between the PON2 S331C gene 
      polymorphism and the serum levels of AOPP, ROMs and BAP was found. Thus, compared 
      with AGE, the levels of AOPP and ROMs provided a more sensitive biomarker, with 
      an improved association with the PON2 genotype. Such an association strengthen 
      the importance of PON in the occurrence of oxidative stress. According to these 
      results, an individual's genetic background may be taken into account for the 
      health surveillance of individuals occupationally exposed to pesticides, in order 
      to define a cluster of highly susceptible workers so as to guarantee greater 
      protection.
FAU - Costa, Chiara
AU  - Costa C
AD  - Department of Clinical and Experimental Medicine, University of Messina, I‑98125 
      Messina, Italy.
FAU - Briguglio, Giusi
AU  - Briguglio G
AD  - Department of Biomedical and Dental Sciences and Morpho‑Functional Imaging, 
      Occupational Medicine Section, University of Messina, I‑98125 Messina, Italy.
FAU - Giambo, Federica
AU  - Giambo F
AD  - Department of Biomedical and Dental Sciences and Morpho‑Functional Imaging, 
      Occupational Medicine Section, University of Messina, I‑98125 Messina, Italy.
FAU - Catanoso, Rosaria
AU  - Catanoso R
AD  - Department of Biomedical and Dental Sciences and Morpho‑Functional Imaging, 
      Occupational Medicine Section, University of Messina, I‑98125 Messina, Italy.
FAU - Teodoro, Michele
AU  - Teodoro M
AD  - Department of Biomedical and Dental Sciences and Morpho‑Functional Imaging, 
      Occupational Medicine Section, University of Messina, I‑98125 Messina, Italy.
FAU - Caccamo, Daniela
AU  - Caccamo D
AD  - Department of Biomedical and Dental Sciences and Morpho‑Functional Imaging, 
      Occupational Medicine Section, University of Messina, I‑98125 Messina, Italy.
FAU - Fenga, Concettina
AU  - Fenga C
AD  - Department of Biomedical and Dental Sciences and Morpho‑Functional Imaging, 
      Occupational Medicine Section, University of Messina, I‑98125 Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200316
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Pesticides)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
SB  - IM
MH  - Antioxidants/metabolism
MH  - Aryldialkylphosphatase/*genetics
MH  - Biomarkers/*metabolism
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/adverse effects
MH  - Oxidative Stress/*genetics
MH  - Pesticides/*adverse effects
MH  - Polymorphism, Genetic/*genetics
EDAT- 2020/03/19 06:00
MHDA- 2021/01/22 06:00
CRDT- 2020/03/19 06:00
PHST- 2019/11/05 00:00 [received]
PHST- 2020/01/10 00:00 [accepted]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/01/22 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
AID - 10.3892/ijmm.2020.4541 [doi]
PST - ppublish
SO  - Int J Mol Med. 2020 Jun;45(6):1951-1959. doi: 10.3892/ijmm.2020.4541. Epub 2020 
      Mar 16.