PMID- 32187318
OWN - NLM
STAT- MEDLINE
DCOM- 20200907
LR  - 20210110
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Print)
IS  - 1516-4446 (Linking)
VI  - 42
IP  - 4
DP  - 2020 Aug
TI  - Impact of metabolic syndrome and clinical features on functioning in patients 
      with bipolar disorder: a cross-sectional study.
PG  - 373-381
LID - S1516-44462020005006201 [pii]
LID - 10.1590/1516-4446-2019-0622 [doi]
AB  - OBJECTIVE: The metabolic syndrome (MS) is highly prevalent among patients with 
      bipolar disorder (BD), and may affect progression, functioning, and comorbid 
      conditions in BD. The aim of this study was to investigate the effect of clinical 
      variables and MS on overall functioning and specific areas of functioning in 
      patients with BD. METHODS: A total of 210 participants (140 participants with BD 
      I and BD II in remission and 70 non-psychiatric control subjects) were included. 
      The investigators administered the Young Mania Rating Scale (YMRS), the Bipolar 
      Depression Rating Scale (BDRS), the Global Assessment of Functioning Scale (GAF), 
      and the Bipolar Disorder Functioning Scale (BDFS). The participants completed the 
      Beck Depression Scale (BDS) and the Beck Anxiety Scale (BAS). MS was diagnosed 
      according to the National Cholesterol Education Program Adult Treatment Panel III 
      (NCEP ATP III) criteria. Hierarchical regression analysis was used to investigate 
      potential correlations of comorbid MS with clinical variables and level of 
      functioning. RESULTS: Level of functioning did not differ between patients with 
      and without MS. However, there were significant correlations between the level of 
      functioning subscales and the number of depressive episodes (p = 0.033), level of 
      general functioning (p = 0.012), duration of illness (p = 0.012), BDS (p = 
      0.005), BDRS (p = 0.021), BAS total scores (p = 0.021), number of hypomanic 
      episodes (p = 0.022), number of hospitalizations (p = 0.003), employment status 
      (p = 0.032), and diagnosis of BD I (p = 0.007) and BD II (p = 0.044). CONCLUSION: 
      Our findings suggest that clinical variables had a greater effect on functioning 
      than MS in BD patients.
FAU - Kocakaya, Hanife
AU  - Kocakaya H
AD  - Dr. Cevdet Aykan Mental Health and Diseases Hospital, Tokat, Turkey.
FAU - Songur, Emrah
AU  - Songur E
AD  - Kecioren Education and Research Hospital, Ankara, Turkey.
FAU - Batmaz, Sedat
AU  - Batmaz S
AD  - Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey.
FAU - Celikbas, Zekiye
AU  - Celikbas Z
AD  - Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey.
FAU - Kucuk, Onder
AU  - Kucuk O
AD  - Dr. Cevdet Aykan Mental Health and Diseases Hospital, Tokat, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200316
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*epidemiology
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Metabolic Syndrome/*epidemiology
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
PMC - PMC7430392
COIS- The authors report no conflicts of interest.
EDAT- 2020/03/19 06:00
MHDA- 2020/09/08 06:00
PMCR- 2020/03/16
CRDT- 2020/03/19 06:00
PHST- 2019/07/24 00:00 [received]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2020/09/08 06:00 [medline]
PHST- 2020/03/19 06:00 [entrez]
PHST- 2020/03/16 00:00 [pmc-release]
AID - S1516-44462020005006201 [pii]
AID - 10.1590/1516-4446-2019-0622 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2020 Aug;42(4):373-381. doi: 10.1590/1516-4446-2019-0622. Epub 
      2020 Mar 16.