PMID- 32187613
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20210401
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 50
IP  - 1
DP  - 2020 Mar 31
TI  - Measurement of peripheral arterial tonometry in patients with diabetic foot 
      ulcers during courses of hyperbaric oxygen treatment.
PG  - 17-23
LID - 10.28920/dhm50.1.17-23 [doi]
AB  - INTRODUCTION: Treatment of diabetic foot ulcers is complex and often protracted. 
      Hyperbaric oxygen treatment (HBOT) improves wound healing in diabetic ulcers and 
      serves as an important adjunct to regular diabetic wound care. Endothelial 
      dysfunction plays a central role in diabetes-related vascular complications and 
      may be evaluated by a non-invasive technique called peripheral arterial tonometry 
      which measures a reactive hyperaemia index (RHI). We hypothesized that 
      endothelial function measured by peripheral arterial tonometry is impaired in 
      diabetic foot ulcer patients and that HBOT might improve endothelial function. 
      METHODS: Endothelial function was prospectively assessed by peripheral arterial 
      tonometry in 22 subjects with diabetic foot ulcers and 17 subjects without 
      diabetes during courses of HBOT. Endothelial function was evaluated before first 
      (baseline) and 30th treatments, and at 90-day follow-up. Serum insulin growth 
      factor-I (IGF-I) concentrations were determined by immunoassay. Results were 
      compared to 23 healthy subjects. RESULTS: No baseline differences were found in 
      endothelial function between subjects with diabetes, HBOT patients 
      without-diabetes and healthy control subjects (RHI; 1.26, 1.61 and 1.81, 
      respectively). No significant changes in RHI were found in patients with (P = 
      0.17) or without (P = 0.30) diabetes during courses of HBOT. At 90-day follow-up 
      IGF-I was significantly reduced in the subjects with diabetes (P = 0.001) and 
      unchanged in the group without diabetes (P = 0.99). CONCLUSIONS: We found no 
      significant differences in RHI between subjects with diabetic foot ulcers and 
      patients without diabetes, nor improvement in endothelial function assessed by 
      peripheral arterial tonometry during courses of HBOT.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Hedetoft, Morten
AU  - Hedetoft M
AD  - The Hyperbaric Oxygen Treatment Unit, Department of Anaesthesia, Centre of Head 
      and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 
      Denmark.
AD  - Corresponding author: Dr Morten Hedetoft, The Hyperbaric Oxygen Treatment Unit, 
      Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University 
      Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark, 
      morten.friis.fiskbaek.hedetoft@regionh.dk.
FAU - Olsen, Niels V
AU  - Olsen NV
AD  - The Hyperbaric Oxygen Treatment Unit, Department of Anaesthesia, Centre of Head 
      and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 
      Denmark.
FAU - Smidt-Nielsen, Isabel G
AU  - Smidt-Nielsen IG
AD  - The Hyperbaric Oxygen Treatment Unit, Department of Anaesthesia, Centre of Head 
      and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 
      Denmark.
FAU - Wahl, Anna M
AU  - Wahl AM
AD  - The Hyperbaric Oxygen Treatment Unit, Department of Anaesthesia, Centre of Head 
      and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 
      Denmark.
FAU - Bergstrom, Anita
AU  - Bergstrom A
AD  - Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, 
      University of Copenhagen, Denmark.
FAU - Juul, Anders
AU  - Juul A
AD  - Department of Clinical Medicine, University of Copenhagen, Denmark.
AD  - Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, 
      Denmark.
FAU - Hyldegaard, Ole
AU  - Hyldegaard O
AD  - The Hyperbaric Oxygen Treatment Unit, Department of Anaesthesia, Centre of Head 
      and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 
      Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - *Diabetic Foot/therapy
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Oxygen
MH  - Wound Healing
PMC - PMC7276266
OTO - NOTNLM
OT  - Diabetes
OT  - Endothelium
OT  - Hyperbaric Research
OT  - Wounds
EDAT- 2020/03/19 06:00
MHDA- 2020/10/24 06:00
PMCR- 2021/03/31
CRDT- 2020/03/19 06:00
PHST- 2019/06/24 00:00 [received]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2020/03/19 06:00 [entrez]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
PHST- 2021/03/31 00:00 [pmc-release]
AID - 10.28920/dhm50.1.17-23 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2020 Mar 31;50(1):17-23. doi: 10.28920/dhm50.1.17-23.