PMID- 32188397
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 2212-3989 (Electronic)
IS  - 1871-5265 (Linking)
VI  - 21
IP  - 2
DP  - 2021
TI  - Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas 
      aeruginosa in Keratitis.
PG  - 284-288
LID - 10.2174/1871526520666200318111957 [doi]
AB  - Nowadays, the co-infection of different classes of pathogens is a major concern. 
      The objective of this study was to develop a successful therapy for keratitis 
      caused by the co-infection of Candida sp. with Pseudomonas sp, which is difficult 
      to cure. The study is based on a 47 years old male farmer showing redness and 
      watering in the right eye for 15-days. ; Methods: The microbiological examination 
      was performed to isolate the causative organisms, i.e. Pseudomonas aeruginosa and 
      Candida albicans. They were cultured separately along with their co-culture and 
      treated with ciprofloxacin and amphotericin B during the growing stage to predict 
      a definite cure. ; Results: Scanning electron microscope (SEM) results confirmed 
      the inter-specific interaction between the two different types of microorganisms. 
      Amphotericin-B and Ciprofloxacin showed the least MIC value for both organisms in 
      co-culture. ; Conclusion: Treatment with Amphotericin-B and 5% ciprofloxacin 
      effectively hindered the growth of Pseudomonas aeruginosa and Candida albicans, 
      the co-infection of which caused keratitis. This therapy may be successfully 
      implied for such cases of co-infection in the future.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Paul, Debarati
AU  - Paul D
AD  - Amity Institute of Biotechnology, Amity University, Noida, Sector 125, 201313, 
      India.
FAU - Saha, Suman
AU  - Saha S
AD  - Priyamvada Birla Aravind Eye Hospital, Kolkata, 700017, WB, India.
FAU - Singh, Neelam
AU  - Singh N
AD  - Babasaheb Bhimrao ambedkar University, Department of Brain and Cognition Science, 
      226025Lucknow, India.
FAU - Sengupta, Jayansgu
AU  - Sengupta J
AD  - Priyamvada Birla Aravind Eye Hospital, Kolkata, 700017, WB, India.
FAU - Mandal, Santi M
AU  - Mandal SM
AD  - Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur- 
      721302, West Bengal, India.
LA  - eng
PT  - Case Reports
PL  - United Arab Emirates
TA  - Infect Disord Drug Targets
JT  - Infectious disorders drug targets
JID - 101269158
RN  - 7XU7A7DROE (Amphotericin B)
SB  - IM
MH  - Amphotericin B
MH  - Candida albicans
MH  - *Coinfection
MH  - Humans
MH  - *Keratitis
MH  - Male
MH  - Middle Aged
MH  - Pseudomonas aeruginosa
OTO - NOTNLM
OT  - Amphotericin-B
OT  - Candida albicans
OT  - Pseudomonas aeruginosa.
OT  - ciprofloxacin
OT  - co-infection
OT  - keratitis
EDAT- 2020/03/20 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/03/20 06:00
PHST- 2019/10/20 00:00 [received]
PHST- 2020/01/19 00:00 [revised]
PHST- 2020/03/08 00:00 [accepted]
PHST- 2020/03/20 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/03/20 06:00 [entrez]
AID - IDDT-EPUB-105342 [pii]
AID - 10.2174/1871526520666200318111957 [doi]
PST - ppublish
SO  - Infect Disord Drug Targets. 2021;21(2):284-288. doi: 
      10.2174/1871526520666200318111957.