PMID- 32188824
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200402
IS  - 0021-4884 (Print)
IS  - 0021-4884 (Linking)
VI  - 69
IP  - 2
DP  - 2020
TI  - [A CASE OF EOSINOPHILIC GASTROENTERITIS FOUND BY PICA DURING ORAL IMMUNOTHERAPY].
PG  - 123-128
LID - 10.15036/arerugi.69.123 [doi]
AB  - Eosinophilic esophagitis has been reported as a complication of oral 
      immunotherapy (OIT), but there are only a few reports of eosinophilic 
      gastroenteritis (EGE) occurring after OIT. EGE causes eosinophil infiltration 
      into the gastrointestinal (GI) tract and is characterized by various digestive 
      symptoms. We report the case of a 6-year-old boy with EGE. He was diagnosed as 
      having immediate-type food allergies (egg, milk and wheat) by oral food 
      challenges at 1 year of age. OIT for each food was carried out, and the amounts 
      of the offending foods were able to be gradually increased without causing any 
      immediate-type allergy symptoms. However, the total IgE and specific IgE values 
      were remarkably increased at the age of 4 years and 4 months. He first developed 
      oral mucosa symptoms and vomiting at 4 years and 10 months of age, and they 
      gradually worsened. Stopping eggs and milk alleviated the symptoms. Nevertheless, 
      he still occasionally vomited. He started Pica eating disorder (sand and sponge) 
      due to anemia from 5 years and 10 months of age and developed eosinophilia 
      without diarrhea or bloody stool. Upper and lower GI tract endoscopic 
      examinations found no bleeding. The GI mucosa showed eosinophil infiltration of 
      more than 40/high-power field in the stomach and duodenum, so he was diagnosed 
      with EGE. No eosinophils were found in the esophageal mucosa. His GI symptoms and 
      anemia improved on a multiple-food-elimination diet. Patients undergoing OIT 
      should be closely followed up for a long time, and those with GI symptoms should 
      be evaluated by GI endoscopy.
FAU - Nishimura, Koji
AU  - Nishimura K
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Fukuie, Tatsuki
AU  - Fukuie T
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Miyaji, Yumiko
AU  - Miyaji Y
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Inuzuka, Yusuke
AU  - Inuzuka Y
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Toyokuni, Kenji
AU  - Toyokuni K
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Irahara, Makoto
AU  - Irahara M
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Ishikawa, Fumi
AU  - Ishikawa F
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Sato, Miori
AU  - Sato M
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Saito, Mayako
AU  - Saito M
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Yamamoto-Hanada, Kiwako
AU  - Yamamoto-Hanada K
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Narita, Masami
AU  - Narita M
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Nomura, Ichiro
AU  - Nomura I
AD  - Allergy Center, National Center for Child Health and Development.
FAU - Ohya, Yukihiro
AU  - Ohya Y
AD  - Allergy Center, National Center for Child Health and Development.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Arerugi
JT  - Arerugi = [Allergy]
JID - 0241212
RN  - Eosinophilic enteropathy
SB  - IM
MH  - Animals
MH  - Child
MH  - Enteritis/complications/*diagnosis
MH  - Eosinophilia/complications/*diagnosis
MH  - Food Hypersensitivity
MH  - Gastritis/complications/*diagnosis
MH  - Humans
MH  - Immunotherapy/*adverse effects
MH  - Male
MH  - Pica/*etiology
OTO - NOTNLM
OT  - anemia
OT  - eosinophilic gastroenteritis
OT  - food allergy
OT  - oral immunotherapy
OT  - pica
EDAT- 2020/03/20 06:00
MHDA- 2020/04/03 06:00
CRDT- 2020/03/20 06:00
PHST- 2020/03/20 06:00 [entrez]
PHST- 2020/03/20 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
AID - 10.15036/arerugi.69.123 [doi]
PST - ppublish
SO  - Arerugi. 2020;69(2):123-128. doi: 10.15036/arerugi.69.123.