PMID- 32190506
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 12
IP  - 2
DP  - 2020 Feb 11
TI  - Angioimmunoblastic T-cell Lymphoma: An Unusual Case in an Octogenarian.
PG  - e6956
LID - 10.7759/cureus.6956 [doi]
LID - e6956
AB  - Angioimmunoblastic T-cell lymphoma (AITL) is an unusual subtype of mature 
      peripheral T-cell lymphoma originating from the follicular T-helper cells and is 
      often associated with autoimmune disorders. AITL is an aggressive lymphoma, 
      presenting with constitutional symptoms, generalized lymphadenopathy, and 
      hepatosplenomegaly. Immunohistochemistry and biopsy are diagnostic methods. The 
      treatment modalities range from steroids, immunomodulators, and cytotoxic 
      chemotherapy. An 87-year-old female presented to the emergency department with 
      cough, dyspnea, dizziness, night sweats, and unintentional weight loss with 
      multiple discrete swellings over her body for a duration of three days. Her 
      physical exam was significant for tachycardia with dry mucous membranes and 
      generalized lymphadenopathy. However, no hepatosplenomegaly was noted. Laboratory 
      investigations revealed neutrophilic leukocytosis (12.8 K/uL), with elevated 
      inflammatory markers (C-reactive protein of 1.39 mg/dL, sedimentation rate of 86 
      mm/hour). The biopsy of the cervical lymph node revealed atypical lymphoid 
      infiltrates. Flow cytometry showed CD10+ and CD4+/CD8+ T-cells with a minority of 
      CD23+ B-cells, and fluorescence in situ hybridization (FISH) reported gains of 
      the BCL2 gene region on chromosome 18, all of which were suggestive of AITL. She 
      was transferred to an advanced hematology center for staging and targeted 
      therapy. A careful review of the patient with the prompt clinical and 
      histological examination is essential for the correct diagnosis as the 
      differentials are vast due to its non-specific clinical presentation and accurate 
      treatment is a must for complete remission.
CI  - Copyright (c) 2020, Kanderi et al.
FAU - Kanderi, Tejaswi
AU  - Kanderi T
AD  - Medicine, University of Pittsburgh Medical Center Pinnacle, Harrisburg, USA.
FAU - Goel, Siddharth
AU  - Goel S
AD  - Internal Medicine, University of Pittsburgh Medical Center Pinnacle, Harrisburg, 
      USA.
FAU - Shrimanker, Isha
AU  - Shrimanker I
AD  - Internal Medicine, University of Pittsburgh Medical Center Pinnacle, Harrisburg, 
      USA.
FAU - Nookala, Vinod K
AU  - Nookala VK
AD  - Internal Medicine, University of Pittsburgh Medical Center Pinnacle, Harrisburg, 
      USA.
FAU - Singh, Pratiksha
AU  - Singh P
AD  - Internal Medicine, Hackensack Meridian Health, Ocean Medical Center, Brick, USA.
LA  - eng
PT  - Case Reports
DEP - 20200211
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7067515
OTO - NOTNLM
OT  - angioimmunoblastic t-cell lymphoma
OT  - hepatosplenomegaly
OT  - lymph node
OT  - lymphadenopathy
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/03/20 06:00
MHDA- 2020/03/20 06:01
PMCR- 2020/02/11
CRDT- 2020/03/20 06:00
PHST- 2020/03/20 06:00 [entrez]
PHST- 2020/03/20 06:00 [pubmed]
PHST- 2020/03/20 06:01 [medline]
PHST- 2020/02/11 00:00 [pmc-release]
AID - 10.7759/cureus.6956 [doi]
PST - epublish
SO  - Cureus. 2020 Feb 11;12(2):e6956. doi: 10.7759/cureus.6956.