PMID- 32192304
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 1671-0274 (Print)
IS  - 1671-0274 (Linking)
VI  - 23
IP  - 3
DP  - 2020 Mar 25
TI  - [Role of radiotherapy in watch and wait strategy after neoadjuvant trerapy for 
      rectal cancer].
PG  - 252-257
LID - 10.3760/cma.j.cn.441530-20200224-00080 [doi]
AB  - For locally advanced (T3-4/N+M0) rectal cancer (LARC), radiation-based 
      neoadjuvant therapy followed by total mesorectal excision (TME) is the standard 
      treatment. For those who achieved clinical complete response (cCR), a 
      non-operative management called "watch and wait" (W&W) strategery can preserve 
      organ function and improve the life quality. For W&W strategy, radiotherapy is 
      still the core part of neoadjuvant therapy. To increase the tumor response grade 
      and cCR rate is the goal of optimized neoadjuvant regimens. In this review, we 
      summarized the role of radiotherapy in the W&W strategy and discussed the 
      advances of optimized radiation-based neoadjuvant therapy to achieve higher cCR 
      rate, including new radiosensitizing agents, induction and consolidation 
      chemotherapy, combination with immunotherapy, and prolonged interval time. All of 
      the above efforts aim to improve patient survival and quality of life.
FAU - Wang, Y Q
AU  - Wang YQ
AD  - Department of Radiation Oncology, Fudan University Shanghai Cancer Center; 
      Department of Oncology, Shanghai Medical College of Fudan University, Shanghai 
      200032, China.
FAU - Zhang, Z
AU  - Zhang Z
LA  - chi
GR  - 81773357/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Wei Chang Wai Ke Za Zhi
JT  - Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
JID - 101177990
SB  - IM
MH  - Humans
MH  - *Neoadjuvant Therapy
MH  - Neoplasm Recurrence, Local
MH  - Quality of Life
MH  - *Rectal Neoplasms/therapy
MH  - Treatment Outcome
MH  - Watchful Waiting
OTO - NOTNLM
OT  - Radiotherapy
OT  - Rectal neoplasms, locally advanced
OT  - Watch and wait strategy
EDAT- 2020/03/21 06:00
MHDA- 2020/03/24 06:00
CRDT- 2020/03/21 06:00
PHST- 2020/03/21 06:00 [entrez]
PHST- 2020/03/21 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
AID - 10.3760/cma.j.cn.441530-20200224-00080 [doi]
PST - ppublish
SO  - Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Mar 25;23(3):252-257. doi: 
      10.3760/cma.j.cn.441530-20200224-00080.