PMID- 32195931
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 12
DP  - 2020 Mar
TI  - The effect of icariin for infertile women with thin endometrium: A protocol for 
      systematic review.
PG  - e19111
LID - 10.1097/MD.0000000000019111 [doi]
LID - e19111
AB  - BACKGROUND: Thin endometrium, defined as <7 mm of the endometrial thickness 
      around ovulation period, had been identified as a negative factor on pregnancy 
      rate of infertile women. It was considered to be the toughest part in treatment 
      of infertility, because there was a lack of significant effect, although many 
      drugs had been already used. Icariin was one of the major bioactive 
      pharmaceutical constituent extracted from the Chinese herb "Ying Yang Huo," in 
      the genus of Epimedium, and some randomized controlled trials reported its 
      application for thin endometrium. There is no systematic review focusing on the 
      effective of icariin in treating infertile women with thin endometrium, so our 
      review aims to explore it. METHODS: The bibliographic database and electronic 
      library will be systematically searched online, such as MEDLINE, EMBASE, Web of 
      Science, Clinicaltrails.org., China National Knowledge Infrastructure Database 
      (CNKI), Wan fang Database, China Biology Medicine Database (CBM), VIP Science 
      Technology Periodical Database, and Cochrane Library. And the reference listed 
      for potential literatures of included studies will be scanned additionally. 
      Related randomized controlled trials (RCTs) will be collected and selected before 
      January 4, 2020. Trials will be screened by independent reviewers, and the 
      literature will be search in English or Chinese, with the search terms as 
      "Icariin," "Epimedium," "infertile women," "female infertility," "endometrium," 
      "pregnancy rate." The software for Systematic review and Meta-analysis is RevMan 
      5.3. The protocol and the systematic review will be reported according to the 
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols 
      (PRISMA-P) statement. RESULT AND CONCLUSION: The efficacy of icariin to treat 
      thin endometrium will be evaluated, and the conclusion will be published to help 
      clinicians determine treatment strategy for infertile women with thin endometirum 
      by providing medical evidence. REGISTRATION INFORMATION: PROSPERO CRD42019148977.
FAU - Du, Juan
AU  - Du J
AD  - Hospital of Chengdu University of Traditional Chinese Medicine.
AD  - Chengdu University of Traditional Chinese Medicine.
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
FAU - Lu, Hua
AU  - Lu H
AD  - Hospital of Chengdu University of Traditional Chinese Medicine.
FAU - Yu, Xujun
AU  - Yu X
AD  - Chengdu University of Traditional Chinese Medicine.
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
FAU - Dong, Liang
AU  - Dong L
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
FAU - Mi, Ling
AU  - Mi L
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
FAU - Wang, Jinpeng
AU  - Wang J
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
FAU - Zheng, Xia
AU  - Zheng X
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
FAU - Feng, Kai
AU  - Feng K
AD  - The Reproductive & Women-Children Hospital, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, Sichuan, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavonoids)
RN  - VNM47R2QSQ (icariin)
SB  - IM
MH  - China
MH  - Drugs, Chinese Herbal/administration & dosage/adverse effects/*therapeutic use
MH  - Endometrium/*physiopathology
MH  - Female
MH  - Flavonoids/administration & dosage/adverse effects/*therapeutic use
MH  - Humans
MH  - Infertility, Female/*drug therapy
MH  - Randomized Controlled Trials as Topic
PMC - PMC7220221
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/03/21 06:00
MHDA- 2020/04/09 06:00
PMCR- 2020/03/20
CRDT- 2020/03/21 06:00
PHST- 2020/03/21 06:00 [entrez]
PHST- 2020/03/21 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2020/03/20 00:00 [pmc-release]
AID - 00005792-202003200-00009 [pii]
AID - MD-D-20-00183 [pii]
AID - 10.1097/MD.0000000000019111 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Mar;99(12):e19111. doi: 10.1097/MD.0000000000019111.