PMID- 32195933
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 12
DP  - 2020 Mar
TI  - Relationship of ankle-brachial index, vibration perception threshold, and current 
      perception threshold to glycemic variability in type 2 diabetes.
PG  - e19374
LID - 10.1097/MD.0000000000019374 [doi]
LID - e19374
AB  - To explore the relationship of glycemic variability with lower extremity arterial 
      disease (LEAD) and diabetic peripheral neuropathy (DPN).Seventy-eight patients 
      with type 2 diabetes were enrolled. All patients underwent 72-hour dynamic blood 
      glucose monitoring and obtained mean amplitude of glycemic excursions (MAGE), 
      mean of daily differences (MODD), standard deviation of blood glucose (SD), 
      largest amplitude of glycemic excursion (LAGE), mean blood glucose (MBG), T>/=10.0 
      (percentage of time for blood glucose levels >/=10.0 mmol/L), T</=3.9 (percentage of 
      time for blood glucose levels </=3.9 mmol/L), and other glycemic variability 
      parameters. In the meanwhile, in order to explore the correlation of glycemic 
      variability parameters with ankle-brachial index (ABI), vibration perception 
      threshold (VPT), and current perception threshold (CPT), all patients underwent 
      quantitative diabetic foot screening, including ABI for quantitative assessment 
      of lower extremity arterial lesions and VPT and CPT for quantitative assessment 
      of peripheral neuropathy.Patients were divided into abnormal CPT group (n = 21) 
      and normal CPT group (n = 57) according to the CPT values. Compared with the 
      normal CPT group, abnormal CPT group showed significantly higher levels of HbA1c, 
      longer duration of diabetes, and higher levels of T</=3.9 (P < .05). However, there 
      was no significant difference of MAGE, SD, LAGE, MODD, and other glycemic 
      variability parameters between abnormal CPT group and normal CPT group (P > .05). 
      Pearson correlation analysis or Spearman correlation analysis showed that ABI 
      negatively correlated with MBG, T>/=10.0, SD, LAGE, and MAGE (P < .05), but no 
      correlation of ABI with T</=3.9 and MODD (P > .05) was shown. VPT showed a positive 
      correlation with T>/=10.0 (P < .05), but no correlation with other glycemic 
      variability parameters (P > .05). There was no correlation between the other CPT 
      values and the glycemic variability parameters (P > .05), except that the left 
      and right 250 Hz CPT values were positively correlated with T</=3.9 (P > .05).The 
      higher the blood glucose levels, the severer the degree of LEAD and DPN lesions; 
      the higher the incidence of hypoglycemia, the severer the degree of DPN lesions; 
      the greater the fluctuation of blood glucose, the severer the degree of LEAD 
      lesions. However, the glycemic variability was not significantly correlated with 
      DPN.
FAU - Zhang, Chuangbiao
AU  - Zhang C
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
FAU - Tang, Meili
AU  - Tang M
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
FAU - Lu, Xiaohua
AU  - Lu X
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
AD  - College of Nursing, Jinan University, Guangzhou.
FAU - Zhao, Wane
AU  - Zhao W
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
AD  - College of Nursing, Jinan University, Guangzhou.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
AD  - College of Nursing, Jinan University, Guangzhou.
FAU - Liu, Yan
AU  - Liu Y
AD  - Department of Endocrinology, First Affiliated Hospital of Jinan University.
AD  - College of Nursing, Jinan University, Guangzhou.
FAU - Guo, Xiujie
AU  - Guo X
AD  - Department of Endocrinology, Qingyuan People's Hospital, Qingyuan, Guangdong 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Ankle Brachial Index
MH  - Blood Glucose/*analysis
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Diabetic Foot/epidemiology
MH  - Diabetic Neuropathies/*epidemiology
MH  - Female
MH  - Humans
MH  - Lower Extremity/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/*epidemiology
MH  - Severity of Illness Index
MH  - *Vibration
PMC - PMC7220673
COIS- The authors report no conflicts of interest.
EDAT- 2020/03/21 06:00
MHDA- 2020/04/09 06:00
PMCR- 2020/03/20
CRDT- 2020/03/21 06:00
PHST- 2020/03/21 06:00 [entrez]
PHST- 2020/03/21 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2020/03/20 00:00 [pmc-release]
AID - 00005792-202003200-00011 [pii]
AID - MD-D-19-08523 [pii]
AID - 10.1097/MD.0000000000019374 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Mar;99(12):e19374. doi: 10.1097/MD.0000000000019374.