PMID- 32196815
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1099-0879 (Electronic)
IS  - 1063-3995 (Linking)
VI  - 27
IP  - 4
DP  - 2020 Jul
TI  - The evolution of depression in first-episode psychosis: A naturalistic database 
      study.
PG  - 611-620
LID - 10.1002/cpp.2449 [doi]
AB  - Depression is commonly seen in the course of schizophrenia and can occur during 
      any of the phases of the psychotic illness. The present study examines the 
      incidence of depression at baseline and de novo depression in first episode of 
      nonaffective psychoses and the course of depression in the 12 months following 
      first-episode psychosis, any predictive significance of baseline depression with 
      recurrence of depression in the subsequent phases of the psychotic illness. The 
      study was conducted with a clinical sample of 460 patients under the care of a 
      first-episode psychosis programme, and data relating to duration of untreated 
      psychosis, sociodemographic data, Positive and Negative Symptom Scale (PANSS), 
      Global Assessment of Functioning (GAF), and Clinical Global Impression (CGI) were 
      collected. Diagnosis was made by at least two psychiatrists using SCID-1, and 
      depression was measured by Patient Health Questionnaire (PHQ-9). Statistical 
      analysis was performed using SAS version 9. We performed multiple logistic 
      regression analyses to identify the sociodemographic and clinical factors that 
      were associated with depression. Statistical significance was set at p value less 
      than 0.05. We found that baseline depression was present in 34.42% patients with 
      a preponderance of females (p = 0.047) and in those with secondary education. A 
      suicide attempt is a strong predictor for depression at baseline. There was lower 
      incidence of depression in those diagnosed with brief psychotic disorder (p = 
      0.015) and those with lower PANSS positive scores (p = 0.017). De novo depression 
      over 12 months was 9.44%. Depression at 1-year follow-up was significantly 
      predicted by depression at baseline.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Basu, Sutapa
AU  - Basu S
AUID- ORCID: 0000-0002-6393-3540
AD  - Early Psychosis Intervention Program, Institute of Mental Health, Singapore.
AD  - Education Office, DUKE-NUS, Singapore.
FAU - Verma, Swapna
AU  - Verma S
AD  - Early Psychosis Intervention Program, Institute of Mental Health, Singapore.
AD  - Education Office, DUKE-NUS, Singapore.
FAU - Abdin, Edimansyah
AU  - Abdin E
AD  - Research Division, Institute of Mental Health, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20200325
PL  - England
TA  - Clin Psychol Psychother
JT  - Clinical psychology & psychotherapy
JID - 9416196
SB  - IM
MH  - Adult
MH  - Depression/*complications/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*psychology
MH  - Recurrence
MH  - Schizophrenia/*complications
MH  - *Schizophrenic Psychology
MH  - Suicide, Attempted
OTO - NOTNLM
OT  - de novo depression
OT  - depression
OT  - first-episode psychosis
OT  - sociodemographic correlates
EDAT- 2020/03/21 06:00
MHDA- 2023/02/25 06:00
CRDT- 2020/03/21 06:00
PHST- 2019/10/10 00:00 [received]
PHST- 2020/03/17 00:00 [revised]
PHST- 2020/03/17 00:00 [accepted]
PHST- 2020/03/21 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2020/03/21 06:00 [entrez]
AID - 10.1002/cpp.2449 [doi]
PST - ppublish
SO  - Clin Psychol Psychother. 2020 Jul;27(4):611-620. doi: 10.1002/cpp.2449. Epub 2020 
      Mar 25.