PMID- 32197451
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231113
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 3
DP  - 2020 Mar 18
TI  - Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux 
      Disease on Postoperative Nausea and Vomiting.
LID - 10.3390/jcm9030825 [doi]
LID - 825
AB  - Postoperative nausea and vomiting (PONV) are common complications after 
      anesthesia, but no study has considered the effects of a proton pump inhibitor 
      (PPI) and gastroesophageal reflux disease (GERD) on PONV at the same time. Thus, 
      we investigated the effects of a PPI and GERD on PONV. Patients aged >/=18 years 
      who underwent general anesthesia between 2010 and 2019 were enrolled. In total, 
      202,439 patients were included and 21,361 In a multivariate analysis, the OR for 
      PONV was higher in subjects with GERD (OR, 1.157; 95% CI, 1.032-1.298; p = 
      0.012). The OR was lower for subjects with taking a PPI (OR, 0.890; 95% CI, 
      0.832-0.953; p < 0.0001). In patients without GERD, the incidence of PONV was 
      lower when lansoprazole (OR, 0.801; 95% CI, 0.718-0.894; p < 0.0001), 
      pantoprazole (OR, 0.856; 95% CI, 0.748-0.980; p = 0.025) and ilaprazole (OR, 
      0.391; 95% CI, 0.158-0.966; p = 0.042) were taken. However, in GERD patients, all 
      PPIs did not show reducing the incidence of PONV. Taken together, the results 
      show that a lansoprazole, pantoprazole, and ilaprazole reduced PONV in patients 
      without GERD, and PPI could not reduce PONV in patients with GERD.
FAU - Kwon, Young Suk
AU  - Kwon YS
AUID- ORCID: 0000-0001-7753-8464
AD  - Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, 
      College of Medicine, Hallym University, Chuncheon 24253, Korea.
AD  - Institute of New Frontier Research Team, Hallym University, Chuncheon 24253, 
      Korea.
FAU - Choi, Jun Woo
AU  - Choi JW
AD  - Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, 
      College of Medicine, Hallym University, Chuncheon 24253, Korea.
FAU - Lee, Ho Seok
AU  - Lee HS
AD  - Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, 
      College of Medicine, Hallym University, Chuncheon 24253, Korea.
AD  - Institute of New Frontier Research Team, Hallym University, Chuncheon 24253, 
      Korea.
FAU - Kim, Jong Ho
AU  - Kim JH
AUID- ORCID: 0000-0002-3818-2239
AD  - Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, 
      College of Medicine, Hallym University, Chuncheon 24253, Korea.
AD  - Institute of New Frontier Research Team, Hallym University, Chuncheon 24253, 
      Korea.
FAU - Kim, Youngmi
AU  - Kim Y
AD  - Institute of New Frontier Research Team, Hallym University, Chuncheon 24253, 
      Korea.
FAU - Lee, Jae Jun
AU  - Lee JJ
AD  - Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, 
      College of Medicine, Hallym University, Chuncheon 24253, Korea.
AD  - Institute of New Frontier Research Team, Hallym University, Chuncheon 24253, 
      Korea.
LA  - eng
GR  - NRF-2017M3A9E8049714/National Research Foundation of Korea/
GR  - NRF-2017M3A9E8033205/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20200318
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7141242
OTO - NOTNLM
OT  - gastroesophageal reflux disease
OT  - postoperative nausea and vomiting
OT  - proton pump inhibitor
COIS- The authors declare no conflicts of interest.
EDAT- 2020/03/22 06:00
MHDA- 2020/03/22 06:01
PMCR- 2020/03/18
CRDT- 2020/03/22 06:00
PHST- 2020/02/20 00:00 [received]
PHST- 2020/03/13 00:00 [revised]
PHST- 2020/03/14 00:00 [accepted]
PHST- 2020/03/22 06:00 [entrez]
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2020/03/22 06:01 [medline]
PHST- 2020/03/18 00:00 [pmc-release]
AID - jcm9030825 [pii]
AID - jcm-09-00825 [pii]
AID - 10.3390/jcm9030825 [doi]
PST - epublish
SO  - J Clin Med. 2020 Mar 18;9(3):825. doi: 10.3390/jcm9030825.