PMID- 32197507
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20211204
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 11
IP  - 3
DP  - 2020 Mar 18
TI  - Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis.
LID - 10.3390/genes11030323 [doi]
LID - 323
AB  - Dendritic cells (DCs) play a critical role in the immune system which sense 
      pathogens and present their antigens to prime the adaptive immune responses. As 
      the progression of sepsis occurs, DCs are capable of orchestrating the aberrant 
      innate immune response by sustaining the Th1/Th2 responses that are essential for 
      host survival. Hence, an in-depth understanding of the characteristics of DCs 
      would have a beneficial effect in overcoming the obstacle occurring in sepsis. 
      This paper focuses on the role of DCs in the progression of sepsis and we also 
      discuss the reverse sepsis-induced immunosuppression through manipulating the DC 
      function. In addition, we highlight some potent immunotherapies that could be 
      used as a novel strategy in the early treatment of sepsis.
FAU - Wang, Guoying
AU  - Wang G
AD  - Institute of Biomedical Informatics, College of Medicine, Henan University, 
      Kaifeng 475004, China.
AD  - Joint National Laboratory for Antibody Drug Engineering, school of Basic Medical 
      Sciences, Henan University, Kaifeng 475004, China.
FAU - Li, Xianghui
AU  - Li X
AD  - Institute of Biomedical Informatics, College of Medicine, Henan University, 
      Kaifeng 475004, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Institute of Biomedical Informatics, College of Medicine, Henan University, 
      Kaifeng 475004, China.
FAU - Elgaili Abdalla, Abualgasim
AU  - Elgaili Abdalla A
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Jouf University, Sakaka 2014, Saudi Arabia.
FAU - Teng, Tieshan
AU  - Teng T
AD  - Institute of Biomedical Informatics, College of Medicine, Henan University, 
      Kaifeng 475004, China.
FAU - Li, Yanzhang
AU  - Li Y
AD  - Joint National Laboratory for Antibody Drug Engineering, school of Basic Medical 
      Sciences, Henan University, Kaifeng 475004, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200318
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/drug effects/*immunology
MH  - Humans
MH  - Immunization/*methods
MH  - Immunologic Factors/pharmacology/therapeutic use
MH  - Immunosuppression Therapy/*methods
MH  - Sepsis/*immunology/therapy
PMC - PMC7140865
OTO - NOTNLM
OT  - dendritic cells
OT  - immune modulatory agents
OT  - immunosuppression
OT  - innate and adaptive immune
OT  - sepsis
COIS- The authors declare no conflicts of interest.
EDAT- 2020/03/22 06:00
MHDA- 2021/01/20 06:00
PMCR- 2020/03/01
CRDT- 2020/03/22 06:00
PHST- 2020/02/02 00:00 [received]
PHST- 2020/03/06 00:00 [revised]
PHST- 2020/03/16 00:00 [accepted]
PHST- 2020/03/22 06:00 [entrez]
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - genes11030323 [pii]
AID - genes-11-00323 [pii]
AID - 10.3390/genes11030323 [doi]
PST - epublish
SO  - Genes (Basel). 2020 Mar 18;11(3):323. doi: 10.3390/genes11030323.