PMID- 32198229
OWN - NLM
STAT- MEDLINE
DCOM- 20210802
LR  - 20221207
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 7
IP  - 3
DP  - 2020 May
TI  - HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the 
      Dutch population.
LID - 10.1212/NXI.0000000000000702 [doi]
LID - e702
AB  - OBJECTIVE: To investigate the possible human leukocyte antigen (HLA) association 
      of both myelin oligodendrocyte glycoprotein (MOG-IgG)-associated diseases (MOGAD) 
      and aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum 
      disorders (NMOSDs) in the Dutch population with European ancestry to clarify 
      similarities or differences in the immunogenetic background of both diseases. 
      METHODS: Blood samples from patients in the Dutch national MS/NMOSD expert clinic 
      were tested for MOG-IgG and AQP4-IgG using a cell-based assay. HLA Class I and II 
      genotyping was performed in 43 MOG-IgG-seropositive and 42 AQP4-IgG-seropositive 
      Dutch patients with European ancestry and compared with those of 5,604 Dutch 
      healthy blood donors. RESULTS: No significant HLA association was found in 
      MOG-IgG-seropositive patients. The AQP4-IgG-seropositive patients had a 
      significant higher frequency of HLA-A*01 (61.9% vs 33.7%, OR 3.16, 95% CI, 
      1.707-5.863, p after correction [pc] = 0.0045), HLA-B*08 (61.9% vs 25.6%, OR 
      4.66, 95% CI, 2.513-8.643, pc < 0.0001), and HLA-DRB1*03 (51.2% vs 27.6%, OR 
      2.75, 95% CI, 1.495-5.042, pc = 0.0199) compared with controls. CONCLUSIONS: The 
      present study demonstrates differences in the immunogenetic background of MOGAD 
      and AQP4-IgG-positive NMOSD. The strong positive association with HLA-A*01, 
      -B*08, and -DRB1*03 is suggestive of a role of this haplotype in the etiology of 
      AQP4-IgG-positive NMOSD in patients with European ancestry, whereas in MOGAD no 
      evidence was found for any HLA association in these disorders.
CI  - Copyright (c) 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Bruijstens, Arlette L
AU  - Bruijstens AL
AUID- ORCID: 0000-0002-7990-5894
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands. a.bruijstens@erasmusmc.nl.
FAU - Wong, Yu Yi M
AU  - Wong YYM
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - van Pelt, Danielle E
AU  - van Pelt DE
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - van der Linden, Pieter J E
AU  - van der Linden PJE
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - Haasnoot, Geert W
AU  - Haasnoot GW
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - Hintzen, Rogier Q
AU  - Hintzen RQ
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - Claas, Frans H J
AU  - Claas FHJ
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - Neuteboom, Rinze F
AU  - Neuteboom RF
AUID- ORCID: 0000-0001-6136-4981
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
FAU - Wokke, Beatrijs H A
AU  - Wokke BHA
AD  - From the Department of Neurology (A.L.B., Y.Y.M.W., E.D.P., R.Q.H., R.F.N., 
      B.H.A.W.), Erasmus University Medical Center, Rotterdam; and Department of 
      Immunohaematology and Blood Transfusion (P.J.E.L., G.W.H., F.H.J.C.), Leiden 
      University Medical Center, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200320
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
RN  - 0 (HLA Antigens)
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aquaporin 4/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Demyelinating Autoimmune Diseases, CNS/blood/*genetics/*immunology
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelin-Oligodendrocyte Glycoprotein/*immunology
MH  - Netherlands
MH  - Neuromyelitis Optica/blood/genetics/immunology
MH  - White People
MH  - Young Adult
PMC - PMC7136059
EDAT- 2020/03/22 06:00
MHDA- 2021/08/03 06:00
PMCR- 2020/03/20
CRDT- 2020/03/22 06:00
PHST- 2019/11/18 00:00 [received]
PHST- 2020/02/07 00:00 [accepted]
PHST- 2020/03/22 06:00 [entrez]
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2021/08/03 06:00 [medline]
PHST- 2020/03/20 00:00 [pmc-release]
AID - 7/3/e702 [pii]
AID - NEURIMMINFL2019025643 [pii]
AID - 10.1212/NXI.0000000000000702 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2020 Mar 20;7(3):e702. doi: 
      10.1212/NXI.0000000000000702. Print 2020 May.