PMID- 32198810
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210809
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 96
IP  - 7
DP  - 2020 Dec
TI  - Right ventricular assessment in patients undergoing transcatheter or surgical 
      aortic valve replacement.
PG  - E711-E722
LID - 10.1002/ccd.28861 [doi]
AB  - BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an alternative 
      treatment option to surgical aortic valve replacement (SAVR) in selected 
      high-risk patients. In this study, we aimed to evaluate the prognostic value of 
      right ventricular (RV) functional imaging to predict clinical response to TAVR 
      and SAVR. METHODS: One hundred and ten patients with symptomatic severe aortic 
      valve stenosis (AVS) undergoing successful TAVR and 32 controls undergoing SAVR 
      were prospectively enrolled. Six months follow up (FU) included two-dimensional 
      (2D) transthoracic echocardiography (TTE) with RV deformation imaging. RESULTS: 
      Baseline TTE showed no significant differences between groups (TAVR and SAVR) in 
      conventional left ventricular (LV) and RV functional parameters (LV ejection 
      fraction [LV-EF]: p = .21; tricuspidal annular plane systolic excursion [TAPSE]: 
      1.8 +/- 0.5 cm, 1.9 +/- 0.4 cm, p = .21), and RV strain (right ventricular-global 
      longitudinal strain [RV-GLS] -11.6 +/- 5.2%, -11.5 +/- 6.5%, p = .70). At FU LV 
      function was unchanged in both groups (p > .05); RV function was significantly 
      improved after TAVR (RV-GLS: -11.6 +/- 5.2%, -13.4 +/- 6.1%, p = .005; TAPSE: 
      1.8 +/- 0.5 cm, 1.9 +/- 0.3 cm, p = .05), and worsened after SAVR (RV-GLS: 
      -11.5 +/- 6.5%, -8.9 +/- 5.2%, p = .04; TAPSE: 1.9 +/- 0.4 cm, 1.5 +/- 0.3 cm, p < .001). 
      Functional New York Heart Association (NYHA) class remained unchanged in patients 
      after SAVR (p = .21), and improved after TAVR (p < .001). Baseline RV function 
      was linked with clinical response to TAVR (TAPSE, p < .0001; RV-GLS, p = .04), 
      and the development of RV-GLS was associated with functional worsening after SAVR 
      (p = .05). CONCLUSION: Baseline RV function and changes of right heart mechanics 
      are closely associated with functional improvements after AVR. SAVR, but not 
      TAVR, seems to have detrimental effects on RV-function.
CI  - (c) 2020 The Authors. Catheterization and Cardiovascular Interventions published by 
      Wiley Periodicals, Inc.
FAU - Schueler, Robert
AU  - Schueler R
AD  - Contilia Heart and Vessel Centrum, Department of Cardiology and Angiology, 
      Elisabeth Hospital, Essen, Germany.
FAU - Ozturk, Can
AU  - Ozturk C
AUID- ORCID: 0000-0002-5419-2488
AD  - Heart Centre Bonn, Department of Internal Medicine, Cardiology, Pulmonology and 
      Angiology, University of Bonn, Bonn, Germany.
FAU - Laser, Jasmin Viktoria
AU  - Laser JV
AD  - Heart Centre Bonn, Department of Internal Medicine, Cardiology, Pulmonology and 
      Angiology, University of Bonn, Bonn, Germany.
FAU - Wirth, Fabian
AU  - Wirth F
AD  - Heart Centre Bonn, Department of Internal Medicine, Cardiology, Pulmonology and 
      Angiology, University of Bonn, Bonn, Germany.
FAU - Werner, Nikos
AU  - Werner N
AD  - Heart Centre Bonn, Department of Internal Medicine, Cardiology, Pulmonology and 
      Angiology, University of Bonn, Bonn, Germany.
FAU - Welz, Armin
AU  - Welz A
AD  - Heart Centre Bonn, Department of Cardiovascular Surgery, University Hospital 
      Bonn, Bonn, Germany.
FAU - Nickenig, Georg
AU  - Nickenig G
AD  - Heart Centre Bonn, Department of Internal Medicine, Cardiology, Pulmonology and 
      Angiology, University of Bonn, Bonn, Germany.
FAU - Sinning, Jan-Malte
AU  - Sinning JM
AD  - Heart Centre Bonn, Department of Internal Medicine, Cardiology, Pulmonology and 
      Angiology, University of Bonn, Bonn, Germany.
FAU - Hammerstingl, Christoph
AU  - Hammerstingl C
AD  - Heart and Vessel Medicine Mediapark, Department of Cardiology, Cologne, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200321
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/diagnostic imaging/physiopathology/*surgery
MH  - Aortic Valve Stenosis/diagnostic imaging/physiopathology/*surgery
MH  - Biomechanical Phenomena
MH  - Case-Control Studies
MH  - *Echocardiography, Doppler
MH  - Female
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Time Factors
MH  - *Transcatheter Aortic Valve Replacement/adverse effects
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - *Ventricular Function, Right
OTO - NOTNLM
OT  - SAVR
OT  - TAVR
OT  - aortic stenosis
OT  - right ventricular function
OT  - speckle tracking
EDAT- 2020/03/22 06:00
MHDA- 2021/08/10 06:00
CRDT- 2020/03/22 06:00
PHST- 2019/11/12 00:00 [received]
PHST- 2020/02/22 00:00 [revised]
PHST- 2020/03/15 00:00 [accepted]
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PHST- 2020/03/22 06:00 [entrez]
AID - 10.1002/ccd.28861 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2020 Dec;96(7):E711-E722. doi: 10.1002/ccd.28861. 
      Epub 2020 Mar 21.