PMID- 32198929
OWN - NLM
STAT- MEDLINE
DCOM- 20210611
LR  - 20210611
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 43
IP  - 4
DP  - 2020 Apr
TI  - Noninvasive cardiac output measurement based optimization in nonresponders of 
      cardiac resynchronization therapy.
PG  - 394-401
LID - 10.1111/pace.13904 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) is an important and effective 
      therapy for end-stage heart failure (HF). Nonresponse to CRT is one of the main 
      obstacles to its application in clinical practice. Herein, we investigated the 
      utilization of the optimization technique using noninvasive cardiac output 
      measurement (NICOM) based Mobil-O-Graph device that measures several circulation 
      parameters noninvasively. METHODS: Seventy-five CRT nonresponder HF patients with 
      an implanted CRT device were included. Patients were randomized equally to 3 
      groups: NICOM, echocardiographic, and empirical optimization groups. After 3 
      months of optimization, changes in six minutes walk test (6-MWT), cardiac output 
      (CO), left ventricular ejection fraction (LVEF), and end-systolic volume (LVESV) 
      were measured. New York Heart Association (NYHA) class and hospitalization for HF 
      were also determined. RESULTS: There were no statistically significant 
      differences among the three groups in terms of demographics, baseline 
      characteristics. In the NICOM group, the 6-MWT, LVEF, CO, and LVESV measurements 
      showed significant improvements compared to baseline values (P < .05). There was 
      no significant improvement in 6-MWT, LVEF, CO, NYHA class, and LVESV in Echo and 
      Empirical groups after 3 months (P > .05). 6-MWT, CO, LVESV percentages, and 
      hospitalization for HF were significantly different between the groups (P < .05). 
      In post hoc analyzes, the percentages of the change in 6-MWT, CO, LVESV, and 
      hospitalization for HF were significantly higher in the NICOM group (P < .017). 
      CONCLUSIONS: This study suggests that Mobil-O-Graph device optimization according 
      to CO measures does appear to have potential hemodynamic and clinical benefits in 
      nonresponder CRT patients. Use of Mobil-O-Graph device as an option for 
      optimization of CRT devices can be an attractive method of improving CRT 
      outcomes.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Yenercag, Mustafa
AU  - Yenercag M
AD  - Department of Cardiology, University of Health Sciences, Samsun Training and 
      Research Hospital, Samsun, Turkey.
FAU - Yuksel, Serkan
AU  - Yuksel S
AD  - Department of Cardiology, Ondokuz Mayis University Hospital, Samsun, Turkey.
FAU - Coksevim, Metin
AU  - Coksevim M
AUID- ORCID: 0000-0001-6907-6941
AD  - Department of Cardiology, Ondokuz Mayis University Hospital, Samsun, Turkey.
FAU - Akcay, Murat
AU  - Akcay M
AUID- ORCID: 0000-0002-4610-8514
AD  - Department of Cardiology, Ondokuz Mayis University Hospital, Samsun, Turkey.
FAU - Arslan, Ugur
AU  - Arslan U
AUID- ORCID: 0000-0001-8572-3571
AD  - Department of Cardiology, University of Health Sciences, Samsun Training and 
      Research Hospital, Samsun, Turkey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200407
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - *Cardiac Output
MH  - *Cardiac Resynchronization Therapy
MH  - Diagnostic Techniques, Cardiovascular
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Treatment Failure
OTO - NOTNLM
OT  - cardiac output
OT  - cardiac resynchronization therapy
OT  - echocardiography
OT  - heart failure
OT  - optimization
EDAT- 2020/03/22 06:00
MHDA- 2021/06/12 06:00
CRDT- 2020/03/22 06:00
PHST- 2019/12/10 00:00 [received]
PHST- 2020/03/03 00:00 [revised]
PHST- 2020/03/15 00:00 [accepted]
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2021/06/12 06:00 [medline]
PHST- 2020/03/22 06:00 [entrez]
AID - 10.1111/pace.13904 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2020 Apr;43(4):394-401. doi: 10.1111/pace.13904. Epub 
      2020 Apr 7.