PMID- 32199010
OWN - NLM
STAT- MEDLINE
DCOM- 20210315
LR  - 20220210
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 69
IP  - 2
DP  - 2020 Apr 30
TI  - Methamphetamine exposure during the first, but not the second half of prenatal 
      development, affects social play behavior.
PG  - 319-330
AB  - Methamphetamine (MA), as a psychostimulant drug that crosses the placental 
      barrier, may disrupt the development of social play. The present study aims to 
      examine the effect of prenatal MA (5 mg/kg) exposure during the first 
      (gestational day (GD) 1-11) or second (GD 12-22) halves of prenatal development 
      of rats on social play behavior. To investigate an acute effect of MA on social 
      play in adulthood, juvenile rats were exposed to a dose of 1 mg/kg MA or saline 
      on the test day and tested for social play for 15 min. Prenatal exposure to MA 
      during GD 1-11 increased social play behavior during 5-10 min interval of the 
      test in males but not females. Prenatal MA during GD 12-22 did not influence 
      social play in males nor females. However, social play occurred to a greater 
      extent in GD 12-22 groups compared with GD 1-11. Acute exposure to MA eliminated 
      playful behavior in all groups and decreased social exploration in GD 1-11. Our 
      results suggest that manipulation of prenatal development during the first half 
      of the gestational period has a greater impact on social play behavior than 
      during the second half.
FAU - Sevcikova, M
AU  - Sevcikova M
AD  - Department of Physiology, Third Faculty of Medicine, Charles University, Prague, 
      Czech Republic. romana.slamberova@lf3.cuni.cz.
FAU - Petrikova, I
AU  - Petrikova I
FAU - Slamberova, R
AU  - Slamberova R
LA  - eng
PT  - Journal Article
DEP - 20200323
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Central Nervous System Stimulants/*toxicity
MH  - Female
MH  - Gestational Age
MH  - Male
MH  - Methamphetamine/*toxicity
MH  - Play and Playthings/*psychology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/*psychology
MH  - Rats
MH  - Rats, Wistar
MH  - *Social Behavior
PMC - PMC8565948
EDAT- 2020/03/22 06:00
MHDA- 2021/03/16 06:00
PMCR- 2020/03/23
CRDT- 2020/03/22 06:00
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2021/03/16 06:00 [medline]
PHST- 2020/03/22 06:00 [entrez]
PHST- 2020/03/23 00:00 [pmc-release]
AID - 934230 [pii]
AID - pr69_319 [pii]
AID - 10.33549/physiolres.934230 [doi]
PST - ppublish
SO  - Physiol Res. 2020 Apr 30;69(2):319-330. doi: 10.33549/physiolres.934230. Epub 
      2020 Mar 23.