PMID- 32199011
OWN - NLM
STAT- MEDLINE
DCOM- 20210315
LR  - 20220210
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 69
IP  - 2
DP  - 2020 Apr 30
TI  - The association of systemic inflammatory markers with indicators of stress and 
      cardiac necrosis in patients undergoing aortic valve replacement and 
      revascularization surgeries.
PG  - 261-274
AB  - The aim was to investigate: changes of inflammatory, stress and cardiac response 
      in patients undergoing open heart surgeries up to five days after the procedure; 
      the association between inflammatory, stress and cardiac response and whether 
      changes in a certain marker can predict short-term patient outcome. Ninety 
      patients were divided into three groups, 30 participants each (on-pump,off-pump 
      revascularization and valve replacement group). The following markers were 
      measured:complete blood count, CRP, IL-6, IL-10, leptin, resistin, monocyte 
      chemoattractant protein-1 (MCP-1), cortisol, CK and hsTnT in 5 points. Resistin 
      increased in all three groups. Lower IL-10 levels were found after the surgery 
      and higher levels of leptin and MCP-1 in the off-pump than in the on-pump group. 
      Off-pump group had higher values of IL-6, IL-10, leptin, resistin and MCP-1 and 
      lower levels of CK and hsTnT 24 after surgery than the on-pump group. We found 
      significant correlation between MCP-1 and resistin. The difference between 
      resistin at time points 2 and 3 significantly predicted transfusion needs; while 
      the difference between CRP and resistin before and at the end of the surgery 
      together with the difference between leukocytes at the end and 24 hours after the 
      surgery predicted the use of inotropic agents/vasopressors. Cardiac surgeries 
      cause an increase of inflammatory, stress and cardiac markers. Only resistin 
      correlated with MCP-1 which confirms the link between resistin secreted form 
      infiltrated macrophages and enhanced release of MCP-1.
FAU - Saracevic, A
AU  - Saracevic A
AD  - Department of Medical Laboratory Diagnostics, University Hospital "Sveti Duh", 
      Zagreb, Croatia. andrea.saracevic@gmail.com.
FAU - Medved, I
AU  - Medved I
FAU - Hrabric Vlah, S
AU  - Hrabric Vlah S
FAU - Kozmar, A
AU  - Kozmar A
FAU - Bilic-Zulle, L
AU  - Bilic-Zulle L
FAU - Simundic, A M
AU  - Simundic AM
LA  - eng
PT  - Journal Article
DEP - 20200323
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Disease/*blood/*surgery
MH  - Biomarkers/blood
MH  - Coronary Artery Bypass/*methods/trends
MH  - Coronary Artery Disease/blood/surgery
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Revascularization/*methods/trends
MH  - Necrosis
MH  - Oxidative Stress/*physiology
MH  - Young Adult
PMC - PMC8565944
COIS- Conflict of interest There is no conflict of interest.
EDAT- 2020/03/22 06:00
MHDA- 2021/03/16 06:00
PMCR- 2020/03/23
CRDT- 2020/03/22 06:00
PHST- 2020/03/22 06:00 [pubmed]
PHST- 2021/03/16 06:00 [medline]
PHST- 2020/03/22 06:00 [entrez]
PHST- 2020/03/23 00:00 [pmc-release]
AID - 934243 [pii]
AID - pr69_261 [pii]
AID - 10.33549/physiolres.934243 [doi]
PST - ppublish
SO  - Physiol Res. 2020 Apr 30;69(2):261-274. doi: 10.33549/physiolres.934243. Epub 
      2020 Mar 23.