PMID- 32199166 OWN - NLM STAT- MEDLINE DCOM- 20200610 LR - 20200610 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 252 DP - 2020 Aug TI - Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice. PG - 126484 LID - S0045-6535(20)30677-9 [pii] LID - 10.1016/j.chemosphere.2020.126484 [doi] AB - An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to POPs on colorectal cancer and gut microbiota. This study characterized the influence of exposure to a human relevant mixture of POPs during gestation and lactation on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly, the maternal POP exposure decreased colonic tumor burden, as shown by light microscopy and histopathological evaluation, indicating a restriction of colorectal carcinogenesis. (1)H nuclear magnetic resonance spectroscopy-based metabolomic analysis identified alterations in the metabolism of amino acids, lipids, glycerophospholipids and energy in intestinal tissue. In addition, 16S rRNA sequencing of gut microbiota indicated that maternal exposure modified fecal bacterial composition. In conclusion, the results showed that early-life exposure to a mixture of POPs reduced colorectal cancer initiation and promotion, possibly through modulation of the microbial and biochemical environment. Further studies should focus on the development of colorectal cancer after combined maternal and dietary exposures to environmentally relevant low-dose POP mixtures. CI - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Johanson, Silje M AU - Johanson SM AD - Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: silje.modahl.johanson@nmbu.no. FAU - Swann, Jonathan R AU - Swann JR AD - Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom. Electronic address: j.swann@imperial.ac.uk. FAU - Umu, Ozgun C O AU - Umu OCO AD - Department of Paraclinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: ozgun.umu@nmbu.no. FAU - Aleksandersen, Mona AU - Aleksandersen M AD - Department of Preclinical Sciences and Pathology, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: mona.aleksandersen@nmbu.no. FAU - Muller, Mette H B AU - Muller MHB AD - Department of Paraclinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: mette.helen.bjorge.muller@nmbu.no. FAU - Berntsen, Hanne F AU - Berntsen HF AD - Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway; National Institute of Occupational Health, P.O. Box 5330 Majorstuen, NO-0304, Oslo, Norway. Electronic address: Hanne.Berntsen@stami.no. FAU - Zimmer, Karin E AU - Zimmer KE AD - Department of Preclinical Sciences and Pathology, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: karin.zimmer@nmbu.no. FAU - Ostby, Gunn C AU - Ostby GC AD - Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: gunn.ostby@nmbu.no. FAU - Paulsen, Jan E AU - Paulsen JE AD - Department of Paraclinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: jan.erik.paulsen@nmbu.no. FAU - Ropstad, Erik AU - Ropstad E AD - Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, NO-0102, Oslo, Norway. Electronic address: erik.ropstad@nmbu.no. LA - eng PT - Journal Article DEP - 20200313 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Carcinogens) RN - 0 (Environmental Pollutants) RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Animals MH - Carcinogenesis MH - Carcinogens/*metabolism/toxicity MH - Colonic Neoplasms MH - Colorectal Neoplasms/chemically induced MH - Environmental Pollutants/*metabolism/toxicity MH - Female MH - Gastrointestinal Microbiome/genetics MH - Humans MH - Lactation MH - Maternal Exposure/statistics & numerical data MH - Metabolomics MH - Mice MH - Mice, Inbred Strains MH - Microbiota MH - RNA, Ribosomal, 16S OTO - NOTNLM OT - Colorectal cancer OT - Gut microbiota OT - Metabolomics OT - Persistent organic pollutants COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/03/22 06:00 MHDA- 2020/06/11 06:00 CRDT- 2020/03/22 06:00 PHST- 2020/01/24 00:00 [received] PHST- 2020/03/10 00:00 [revised] PHST- 2020/03/12 00:00 [accepted] PHST- 2020/03/22 06:00 [pubmed] PHST- 2020/06/11 06:00 [medline] PHST- 2020/03/22 06:00 [entrez] AID - S0045-6535(20)30677-9 [pii] AID - 10.1016/j.chemosphere.2020.126484 [doi] PST - ppublish SO - Chemosphere. 2020 Aug;252:126484. doi: 10.1016/j.chemosphere.2020.126484. Epub 2020 Mar 13.