PMID- 32199722
OWN - NLM
STAT- MEDLINE
DCOM- 20210212
LR  - 20210212
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 28
IP  - 2
DP  - 2021 Feb
TI  - Application of Multiparametric Quantitative Cardiac Magnetic Resonance for 
      Detection and Monitoring of Myocardial Injury in Patients with Fulminant 
      Myocarditis.
PG  - e35-e43
LID - S1076-6332(20)30083-0 [pii]
LID - 10.1016/j.acra.2020.01.034 [doi]
AB  - RATIONALE AND OBJECTIVES: To investigate whether multiparametric cardiac magnetic 
      resonance (CMR) could detect and monitor inflammatory myocardial alterations in 
      fulminant myocarditis. MATERIALS AND METHODS: Nineteen patients (35 +/- 14 years, 
      37% male) with clinical diagnosis of fulminant myocarditis underwent CMR 
      examinations at 3.0T in the acute phase and at 3-months follow up. The control 
      group consisted of 19 healthy volunteers. The CMR protocol included cine, black 
      blood T2-weighted imaging, T1 mapping, T2 mapping and late gadolinium enhancement 
      (LGE). Cardiac parameters, such as edema ratio, LGE mass, native T1, T2 and 
      extracellular volume were measured. RESULTS: The left ventricular mass index (67 
      +/- 15 versus 55 +/- 12 g/m(2), p < 0.05) and interventricular septum thickness (10.4 
      +/- 1.5 versus 8.3 +/- 1.8 mm, p < 0.001) in acute stage was significantly higher 
      compared to controls, and normalized at the chronic stage. All quantitative 
      inflammation metrics, including edema ratio, LGE mass, native T1, T2 and 
      extracellular volume were significantly (all p < 0.001) decreased in the 
      follow-up scan, but still higher compared to controls. Compared to the controls, 
      all global strain indices including circumferential, longitudinal and radial 
      strain values were significantly impaired in acute stage (all p < 0.001). Native 
      T1 and T2 values led to excellent diagnostic accuracy for discriminating 
      fulminant myocarditis from healed myocarditis, with AUC of 0.947 and 0.931. 
      CONCLUSION: Multiparametric CMR could detect and monitor inflammation myocardial 
      injuries in patients with fulminant myocarditis. Native T1 and T2 values achieved 
      excellent diagnostic performance in distinguishing acute from healed myocarditis.
CI  - Copyright (c) 2020 The Association of University Radiologists. Published by 
      Elsevier Inc. All rights reserved.
FAU - Li, Haojie
AU  - Li H
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Zhu, Hui
AU  - Zhu H
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Yang, Zhaoxia
AU  - Yang Z
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Tang, Dazhong
AU  - Tang D
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Huang, Lu
AU  - Huang L
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Xia, Liming
AU  - Xia L
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China. Electronic 
      address: lmxia@tjh.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200318
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Case-Control Studies
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - *Myocarditis/diagnostic imaging
MH  - Predictive Value of Tests
MH  - Prospective Studies
OTO - NOTNLM
OT  - Inflammation
OT  - Magnetic resonance imaging
OT  - Myocarditis
OT  - Strain
EDAT- 2020/03/23 06:00
MHDA- 2021/02/13 06:00
CRDT- 2020/03/23 06:00
PHST- 2019/11/25 00:00 [received]
PHST- 2020/01/29 00:00 [revised]
PHST- 2020/01/29 00:00 [accepted]
PHST- 2020/03/23 06:00 [pubmed]
PHST- 2021/02/13 06:00 [medline]
PHST- 2020/03/23 06:00 [entrez]
AID - S1076-6332(20)30083-0 [pii]
AID - 10.1016/j.acra.2020.01.034 [doi]
PST - ppublish
SO  - Acad Radiol. 2021 Feb;28(2):e35-e43. doi: 10.1016/j.acra.2020.01.034. Epub 2020 
      Mar 18.