PMID- 32200256
OWN - NLM
STAT- MEDLINE
DCOM- 20210126
LR  - 20210126
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 126
DP  - 2020 Jun
TI  - Thyme oxymel by improving of inflammation, oxidative stress, dyslipidemia and 
      homeostasis of some trace elements ameliorates obesity induced by 
      high-fructose/fat diet in male rat.
PG  - 110079
LID - S0753-3322(20)30270-5 [pii]
LID - 10.1016/j.biopha.2020.110079 [doi]
AB  - OBJECTIVE: Thyme oxymel is a mixture of vinegar, sugar and thyme which is 
      traditionally used in many folk medicines as syrup to treat metabolic disorders. 
      The molecular mechanisms of anti-hyperlipidemic and anti-inflammatory and 
      antioxidant effects of thyme oxymel or oxymel and its role on homeostasis of 
      trace elements are not fully understood. The aim of this study was to evaluate 
      the anti-inflammatory, antioxidant and anti- hyperlipidemic effects of different 
      doses of thyme oxymel and oxymel on obesity induced by high-fat/-fructose diet 
      (HFFD) in male rat. METHODS: Eighty adult male Sprague-Dawley rats were randomly 
      divided into eleven groups and treated daily for 24 weeks. At the end of the 
      study, serum levels of liver enzymes, lipid profiles, blood glucose, insulin, 
      antioxidant enzymes and lipid peroxidation and TNF-alpha were measured. The hepatic 
      oxidative biomarkers and the genes expression of SREBP-1c, CPT-1, Nrf-2 and NF-kappaB 
      were also studied to determine the molecular mechanism involved in this disease. 
      RESULTS: The results showed that HFFD could significantly change the level of 
      oxidative biomarkers, lipid profiles, TNF-alpha, liver enzymes, leptin, insulin and 
      the levels of some trace elements in obese rats compared to control group (p < 
      0.05), while pretreatment and treatment with thyme oxymel and oxymel in obese 
      rats could significantly ameliorate them and bring some of them back to normal (p 
      < 0.05).The molecular results also showed that HFFD significantly up-regulated 
      the expression of SREBP-1c and NF-kappaB and down-regulated CPT-1 and Nrf-2 
      expression(p < 0.05). While, pretreatment and treatment with thyme oxymel or 
      oxymel in obese rats could significantly ameliorate them (p < 0.05). CONCLUSIONS: 
      It can be concluded that thyme oxymel or oxymel can alleviate HFFD-induced 
      obesity through improving oxidative stress, inflammation, lipid metabolism, 
      homeostasis of some trace elements, and weight-regulating hormones.
CI  - Copyright (c) 2020. Published by Elsevier Masson SAS.
FAU - Nimrouzi, Majid
AU  - Nimrouzi M
AD  - Department of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
FAU - Abolghasemi, Jafar
AU  - Abolghasemi J
AD  - Research Center for Traditional Medicine and History of Medicine, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
FAU - Sharifi, Mohammad Hossein
AU  - Sharifi MH
AD  - Research Center for Traditional Medicine and History of Medicine, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
FAU - Nasiri, Khadijeh
AU  - Nasiri K
AD  - Department of Exercise Physiology, Faculty of Sport Sciences, University of 
      Mazandaran, Babolsar, Iran.
FAU - Akbari, Abolfazl
AU  - Akbari A
AD  - Department of Physiology, School of Veterinary Medicine, Shiraz University, 
      Shiraz, Iran. Electronic address: A.akbari@shirazu.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20200319
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Trace Elements)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Antioxidants/chemistry/*pharmacology
MH  - Biomarkers
MH  - Blood Glucose/drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Fructose/administration & dosage/metabolism
MH  - Gas Chromatography-Mass Spectrometry
MH  - Gene Expression
MH  - Homeostasis/*drug effects
MH  - Hypolipidemic Agents/chemistry/*pharmacology
MH  - Immunohistochemistry
MH  - Inflammation Mediators/metabolism
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - *Medicine, Traditional
MH  - Obesity/drug therapy/etiology/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Trace Elements/*metabolism
OTO - NOTNLM
OT  - Inflammation
OT  - Lipid metabolism
OT  - Obesity
OT  - Oxidative stress
OT  - Thyme oxymel
OT  - Traces elements
COIS- Declaration of Competing Interest The authors declare that there is no conflict 
      of interests regarding the publication of this manuscript.
EDAT- 2020/03/23 06:00
MHDA- 2021/01/27 06:00
CRDT- 2020/03/23 06:00
PHST- 2019/12/09 00:00 [received]
PHST- 2020/03/04 00:00 [revised]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/03/23 06:00 [pubmed]
PHST- 2021/01/27 06:00 [medline]
PHST- 2020/03/23 06:00 [entrez]
AID - S0753-3322(20)30270-5 [pii]
AID - 10.1016/j.biopha.2020.110079 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2020 Jun;126:110079. doi: 10.1016/j.biopha.2020.110079. Epub 
      2020 Mar 19.