PMID- 3220120
OWN - NLM
STAT- MEDLINE
DCOM- 19890317
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 158
IP  - 1-2
DP  - 1988 Dec 6
TI  - Capsaicin pretreatment does not inhibit the opioid withdrawal response in 
      guinea-pigs.
PG  - 91-8
AB  - The effects of capsaicin pretreatment on withdrawal responses of guinea-pig 
      isolated ileum to [Met5]enkephalin (ME) and morphine and on the locomotor 
      withdrawal response of guinea-pigs following a single dose of morphine, were 
      investigated. In vitro treatment of ileum with capsaicin, 1.5 mumol/l for 1 h, 
      did not significantly affect the response to washout following 2 min contact with 
      ME, 1 mumol/l, or the withdrawal response precipitated by naloxone, 1 mumol/l, 
      following 2 min contact with morphine, 1 mumol/l, or the response to naloxone of 
      tolerant-dependent ileum obtained from guinea-pigs treated with a total dose of 
      690 mg/kg of morphine over 3 days. Pretreatment of guinea-pigs with capsaicin 140 
      mg/kg subcutaneously (s.c.) over 4 days also did not affect the washout 
      withdrawal response of the ileum to ME. Pretreatment of guinea-pigs with 
      capsaicin did not affect the locomotor withdrawal response precipitated by 
      naloxone hydrochloride 15 mg/kg s.c., 2 h after injection of morphine sulphate 15 
      mg/kg s.c. It was concluded that primary afferent neurones do not play an 
      essential role in opioid withdrawal responses.
FAU - Chahl, L A
AU  - Chahl LA
AD  - Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, 
      N.S.W., Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 76I7G6D29C (Morphine)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Capsaicin/*pharmacology
MH  - Enkephalin, Methionine/*pharmacology
MH  - Female
MH  - Guinea Pigs
MH  - Ileum/drug effects
MH  - In Vitro Techniques
MH  - Male
MH  - Morphine/*toxicity
MH  - Motor Activity/drug effects
MH  - Muscle Contraction/drug effects
MH  - Substance Withdrawal Syndrome/*prevention & control
EDAT- 1988/12/06 00:00
MHDA- 1988/12/06 00:01
CRDT- 1988/12/06 00:00
PHST- 1988/12/06 00:00 [pubmed]
PHST- 1988/12/06 00:01 [medline]
PHST- 1988/12/06 00:00 [entrez]
AID - 0014-2999(88)90257-9 [pii]
AID - 10.1016/0014-2999(88)90257-9 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1988 Dec 6;158(1-2):91-8. doi: 10.1016/0014-2999(88)90257-9.