PMID- 32201298
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20210502
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 192
DP  - 2020 May
TI  - High ambient temperature increases the toxicity and lethality of 
      3,4-methylenedioxymethamphetamine and methcathinone.
PG  - 172912
LID - S0091-3057(19)30422-8 [pii]
LID - 10.1016/j.pbb.2020.172912 [doi]
AB  - RATIONALE: Methylenedioxymethamphetamine (MDMA) and methcathinone (MCAT) are 
      abused psychostimulant drugs that produce adverse effects in human users that 
      include hepatotoxicity and death. Recent work has suggested a connection between 
      hepatotoxicity, elevations in plasma ammonia, and brain glutamate function for 
      methamphetamine (METH)-induced neurotoxicity. OBJECTIVES: These experiments 
      investigated the effect of ambient temperature on the toxicity and lethality 
      produced by MDMA and MCAT in mice, and whether these effects might involve 
      similar mechanisms to those described for METH neurotoxicity. RESULTS: Under low 
      (room temperature) ambient temperature conditions, MDMA induced hepatotoxicity, 
      elevated plasma ammonia levels, and induced lethality. Under the same conditions, 
      even a very high dose of MCAT produced limited toxic or lethal effects. High 
      ambient temperature conditions potentiated the toxic and lethal effects of both 
      MDMA and MCAT. CONCLUSION: These studies suggest that hepatotoxicity, plasma 
      ammonia, and brain glutamate function are involved in MDMA-induced lethality, as 
      has been shown for METH neurotoxicity. The toxicity and lethality of both MDMA 
      and MCAT were potentiated by high ambient temperatures. Although an initial mouse 
      study reported that several cathinones were much less toxic than METH or MDMA, 
      the present results suggest that it will be essential to assess the potential 
      dangers posed by these drugs under high ambient temperatures.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Pharmacology & Experimental Therapeutics, College of Pharmacology 
      and Pharmacological Science, University of Toledo, OH, USA.
FAU - Tran, Huyen T N
AU  - Tran HTN
AD  - Department of Pharmacology & Experimental Therapeutics, College of Pharmacology 
      and Pharmacological Science, University of Toledo, OH, USA.
FAU - Saber, Yasir H
AU  - Saber YH
AD  - Department of Pharmacology & Experimental Therapeutics, College of Pharmacology 
      and Pharmacological Science, University of Toledo, OH, USA; Ninevah College of 
      Medicine, Ninevah University, Mosul, Iraq.
FAU - Hall, F Scott
AU  - Hall FS
AD  - Department of Pharmacology & Experimental Therapeutics, College of Pharmacology 
      and Pharmacological Science, University of Toledo, OH, USA. Electronic address: 
      frank.hall@utoledo.edu.
LA  - eng
GR  - R03 DA045350/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200319
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Propiophenones)
RN  - 386QA522QG (monomethylpropion)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 44RAL3456C (Methamphetamine)
RN  - 7664-41-7 (Ammonia)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Ammonia/blood
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Central Nervous System Stimulants/*toxicity
MH  - Disease Models, Animal
MH  - Female
MH  - Glutamic Acid/metabolism
MH  - *Hot Temperature
MH  - Male
MH  - Methamphetamine/toxicity
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurotoxicity Syndromes/blood/*etiology/*mortality
MH  - Propiophenones/*toxicity
MH  - Signal Transduction/drug effects
MH  - Substance-Related Disorders/mortality
PMC - PMC7294679
MID - NIHMS1579669
OTO - NOTNLM
OT  - Hepatotoxicity
OT  - Hyperthermia
OT  - Hypothermia
OT  - Lethality
OT  - Methcathinone
OT  - Methylenedioxymethamphetamine
OT  - Synthetic cathinones
EDAT- 2020/03/24 06:00
MHDA- 2021/01/23 06:00
PMCR- 2021/05/01
CRDT- 2020/03/24 06:00
PHST- 2019/08/30 00:00 [received]
PHST- 2020/03/12 00:00 [revised]
PHST- 2020/03/19 00:00 [accepted]
PHST- 2020/03/24 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
PHST- 2020/03/24 06:00 [entrez]
PHST- 2021/05/01 00:00 [pmc-release]
AID - S0091-3057(19)30422-8 [pii]
AID - 10.1016/j.pbb.2020.172912 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2020 May;192:172912. doi: 10.1016/j.pbb.2020.172912. 
      Epub 2020 Mar 19.