PMID- 32201905
OWN - NLM
STAT- MEDLINE
DCOM- 20200923
LR  - 20220415
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 57
IP  - 8
DP  - 2020 Aug
TI  - Changes in corneal biomechanics in patients with diabetes mellitus: a systematic 
      review and meta-analysis.
PG  - 973-981
LID - 10.1007/s00592-020-01481-0 [doi]
AB  - AIMS: To determine the changes in corneal biomechanical parameters in patients 
      with diabetes mellitus (DM) in comparison with controls. METHODS: Pertinent 
      studies were identified by comprehensively search of PubMed, Embase, the Web of 
      Science, the Cochrane Library, Scopus, the China National Knowledge 
      Infrastructure and the Chinese biomedical disc (CBM) databases. Pooling analyses 
      by random models using the D-L method were performed for corneal hysteresis (CH), 
      the corneal resistance factor (CRF), corneal-compensated intraocular pressure 
      (IOPcc) and Goldmann-correlated intraocular pressure (IOPg). RESULTS: A total of 
      15 studies were included in the final analysis, involving 1506 eyes in the 
      diabetic group and 2190 eyes in the control group. The diabetic group had 
      significantly higher CH, CRF, IOPg and IOPcc values than the control group. The 
      pooled mean differences were 1.34 mmHg (95% confidence interval [CI] 
      0.60-2.08 mmHg, P < 0.001) for IOPg and 0.85 mmHg (95% CI 0.18-1.51 mmHg, 
      P = 0.013) for IOPcc, 0.38 mmHg (95% CI 0.01-0.75, P = 0.047) for CH and 
      0.63 mmHg (95% CI 0.27-0.98, P = 0.001) for the CRF. Sensitivity analyses using 
      the leave-one-out method showed a consistent significant difference between the 
      groups (all P < 0.001). CONCLUSIONS: Corneal biomechanics changed in the patients 
      with DM. High CH, CRF, IOPcc and IOPg values may be associated factors for 
      diabetes mellitus. Future studies are warranted to clarify the underlying 
      mechanisms and explore the relationship between corneal biomechanics, glaucoma 
      and diabetes mellitus. REGISTRATION: PROSPERO registration No CRD4201705465.
FAU - Wang, Xiaoyi
AU  - Wang X
AD  - Department of Ophthalmology Center, Huizhou Municipal Central Hospital, Huizhou, 
      Guangdong Province, People's Republic of China.
FAU - Xu, Guihua
AU  - Xu G
AD  - Department of Ophthalmology Center, Huizhou Municipal Central Hospital, Huizhou, 
      Guangdong Province, People's Republic of China.
FAU - Wang, Wei
AU  - Wang W
AUID- ORCID: 0000-0002-5273-3332
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen 
      University, Guangzhou, People's Republic of China.
FAU - Wang, Juanjuan
AU  - Wang J
AD  - Department of Ophthalmology Center, Huizhou Municipal Central Hospital, Huizhou, 
      Guangdong Province, People's Republic of China.
FAU - Chen, Lili
AU  - Chen L
AD  - Department of Ophthalmology Center, Huizhou Municipal Central Hospital, Huizhou, 
      Guangdong Province, People's Republic of China.
FAU - He, Mingguang
AU  - He M
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen 
      University, Guangzhou, People's Republic of China.
FAU - Chen, Zilin
AU  - Chen Z
AD  - Department of Ophthalmology Center, Huizhou Municipal Central Hospital, Huizhou, 
      Guangdong Province, People's Republic of China. boydongdong1@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200322
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Biomechanical Phenomena
MH  - Case-Control Studies
MH  - Cornea/*physiopathology
MH  - Diabetes Mellitus/*physiopathology
MH  - Diabetic Retinopathy/etiology/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Tonometry, Ocular
OTO - NOTNLM
OT  - Corneal biomechanics
OT  - Diabetes mellitus
OT  - Glaucoma
OT  - Meta-analysis
EDAT- 2020/03/24 06:00
MHDA- 2020/09/24 06:00
CRDT- 2020/03/24 06:00
PHST- 2019/10/21 00:00 [received]
PHST- 2020/01/10 00:00 [accepted]
PHST- 2020/03/24 06:00 [pubmed]
PHST- 2020/09/24 06:00 [medline]
PHST- 2020/03/24 06:00 [entrez]
AID - 10.1007/s00592-020-01481-0 [pii]
AID - 10.1007/s00592-020-01481-0 [doi]
PST - ppublish
SO  - Acta Diabetol. 2020 Aug;57(8):973-981. doi: 10.1007/s00592-020-01481-0. Epub 2020 
      Mar 22.