PMID- 32203809
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 138
DP  - 2020 May
TI  - Estrogenic action by tris(2,6-dimethylphenyl) phosphate impairs the development 
      of female reproductive functions.
PG  - 105662
LID - S0160-4120(19)34916-5 [pii]
LID - 10.1016/j.envint.2020.105662 [doi]
AB  - Developmental exposure to environmental chemicals with estrogen-like activity is 
      suspected to permanently impair women's health. In this study, a mouse model was 
      used to evaluate whether tris(2,6-dimethylphenyl) phosphate (TDMPP), a chemical 
      with a putative estrogen-like action, impairs sexual differentiation of the 
      brain. Either TDMPP and 17beta-estradiol (E(2)) as positive controls or sesame oil 
      as a negative control were administered subcutaneously to dams from gestational 
      day (GD) 14 to parturition, and to pups from postnatal day (PND) 0 to 9. 
      Precocious puberty, irregular estrous cycles, and a lowered lordosis response 
      were found in the TDMPP- and E(2)-treated groups. A certain amount of TDMPP and 
      its metabolites in the perinatal brain and the masculinization of sexual 
      dimorphic nuclei in the hypothalamus of female mice after treatment were also 
      detected. The experimental evidence demonstrates that TDMPP directly enters the 
      fetal and neonatal brain, thereby inducing changes of sex-related brain 
      structures and impairing female reproductive functions.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Sano, Kazuhiro
AU  - Sano K
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Japan (NIES), 16-2 Onogawa, Tsukuba 305-8506, Japan.
FAU - Matsukami, Hidenori
AU  - Matsukami H
AD  - Center for Material Cycles and Waste Management Research, NIES, Japan.
FAU - Suzuki, Go
AU  - Suzuki G
AD  - Center for Material Cycles and Waste Management Research, NIES, Japan.
FAU - Htike, Nang Thinn Thinn
AU  - Htike NTT
AD  - Graduate School of Science and Engineering, Saitama University, Japan.
FAU - Morishita, Masahiro
AU  - Morishita M
AD  - Graduate School of Science and Engineering, Saitama University, Japan.
FAU - Win-Shwe, Tin-Tin
AU  - Win-Shwe TT
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Japan (NIES), 16-2 Onogawa, Tsukuba 305-8506, Japan.
FAU - Hashimoto, Shunji
AU  - Hashimoto S
AD  - Center for Environmental Measurement and Analysis, NIES, Japan.
FAU - Kawashima, Takaharu
AU  - Kawashima T
AD  - Center for Environmental Biology and Ecosystem Studies, NIES, Japan.
FAU - Isobe, Tomohiko
AU  - Isobe T
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Japan (NIES), 16-2 Onogawa, Tsukuba 305-8506, Japan.
FAU - Nakayama, Shoji F
AU  - Nakayama SF
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Japan (NIES), 16-2 Onogawa, Tsukuba 305-8506, Japan.
FAU - Tsukahara, Shinji
AU  - Tsukahara S
AD  - Graduate School of Science and Engineering, Saitama University, Japan.
FAU - Maekawa, Fumihiko
AU  - Maekawa F
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Japan (NIES), 16-2 Onogawa, Tsukuba 305-8506, Japan. 
      Electronic address: fmaekawa@nies.go.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200320
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Phosphates)
RN  - 2DI9HA706A (Estrone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - *Estradiol
MH  - Estrone
MH  - Female
MH  - Fetal Development
MH  - Mice
MH  - *Phosphates
MH  - Pregnancy
OTO - NOTNLM
OT  - Environmental chemicals
OT  - Estrogen-like activity
OT  - Sexual differentiation
OT  - Tris(2,6-dimethylphenyl) phosphate
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/03/24 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/03/24 06:00
PHST- 2019/12/28 00:00 [received]
PHST- 2020/03/11 00:00 [revised]
PHST- 2020/03/11 00:00 [accepted]
PHST- 2020/03/24 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/03/24 06:00 [entrez]
AID - S0160-4120(19)34916-5 [pii]
AID - 10.1016/j.envint.2020.105662 [doi]
PST - ppublish
SO  - Environ Int. 2020 May;138:105662. doi: 10.1016/j.envint.2020.105662. Epub 2020 
      Mar 20.