PMID- 32204353
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 10
IP  - 3
DP  - 2020 Mar 19
TI  - Mammary Transcriptome Profile during Peak and Late Lactation Reveals 
      Differentially Expression Genes Related to Inflammation and Immunity in Chinese 
      Holstein.
LID - 10.3390/ani10030510 [doi]
LID - 510
AB  - Somatic cell count (SCC) in milk is widely used in the dairy industry, as an 
      indicator of the health of mammary gland. While the SCC of dairy cattle was 
      higher in late lactation than in peak lactation, its association with gene 
      expressions of mammary gland were largely unknown. In this study, a 
      transcriptomic sequencing approach and bioinformatics analysis were used to 
      investigate the differential expressed genes (DEGs) associated with inflammation 
      and immunity between peak and late periods of lactation in Chinese Holstein. A 
      total of 446 DEGs (padj < 0.05 and fold change >2) were identified, 50 of which 
      belonged to seven pathways and five terms related to inflammation and immunity. 
      Our data suggested that the activation of nuclear transcription factor-kappaB (NF-kappaB) 
      pathway and Toll-like receptor signaling pathway caused inflammatory response, 
      and the activation of chemokine signaling pathway and cytokine-cytokine receptor 
      interaction signaling pathway caused a protective immune response to ensure dairy 
      cows health during late lactation. Our findings deepen the understanding of the 
      molecular mechanism and physiological functions of mammary inflammation in 
      Chinese Holstein during late lactation.
FAU - Han, Ziyin
AU  - Han Z
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      China.
AD  - Joint International Research Laboratory of Agriculture & Agri-Product Safety, 
      Ministry of Education, Yangzhou University, Yangzhou 225009, China.
FAU - Fan, Yongliang
AU  - Fan Y
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      China.
AD  - Joint International Research Laboratory of Agriculture & Agri-Product Safety, 
      Ministry of Education, Yangzhou University, Yangzhou 225009, China.
FAU - Yang, Zhangping
AU  - Yang Z
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      China.
AD  - Joint International Research Laboratory of Agriculture & Agri-Product Safety, 
      Ministry of Education, Yangzhou University, Yangzhou 225009, China.
FAU - Loor, Juan J
AU  - Loor JJ
AD  - Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA.
FAU - Yang, Yi
AU  - Yang Y
AD  - Jiangsu Co-innovation Center for the Prevention and Control of Important Animal 
      Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary 
      Medicine, Yangzhou 225009, China.
LA  - eng
GR  - BK20190881/The Basic Research Program of Jiangsu Province/
GR  - 2019M650126/The China Postdoctoral Science Foundation/
GR  - 31872324/The National Natural Science Foundation of China/
GR  - CX (17) 1005/Jiangsu Agriculture Science and Technology Innovation Fund/
GR  - JATS (2018) 300/The Jiangsu Modern Dairy Industry Technology System/
PT  - Journal Article
DEP - 20200319
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7143190
OTO - NOTNLM
OT  - Chinese Holstein
OT  - differentially expressed genes
OT  - lactation initiation
OT  - mammary gland
OT  - transcriptome
COIS- The authors declare no conflict of interest.
EDAT- 2020/03/25 06:00
MHDA- 2020/03/25 06:01
PMCR- 2020/03/19
CRDT- 2020/03/25 06:00
PHST- 2020/02/02 00:00 [received]
PHST- 2020/03/17 00:00 [revised]
PHST- 2020/03/18 00:00 [accepted]
PHST- 2020/03/25 06:00 [entrez]
PHST- 2020/03/25 06:00 [pubmed]
PHST- 2020/03/25 06:01 [medline]
PHST- 2020/03/19 00:00 [pmc-release]
AID - ani10030510 [pii]
AID - animals-10-00510 [pii]
AID - 10.3390/ani10030510 [doi]
PST - epublish
SO  - Animals (Basel). 2020 Mar 19;10(3):510. doi: 10.3390/ani10030510.