PMID- 32205087
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 254
DP  - 2020 Aug 1
TI  - Dendritic cell therapy in cancer treatment; the state-of-the-art.
PG  - 117580
LID - S0024-3205(20)30328-3 [pii]
LID - 10.1016/j.lfs.2020.117580 [doi]
AB  - Dendritic cells (DCs) are considered as professional antigen presenting cells 
      (APCs), containing a variety of subsets, that can be resident in organs or 
      migrating among the lymphoid and non-lymphoid organs. In a normal steady 
      condition, DCs concomitantly process and present antigens on major 
      histocompatibility complex (MHC) class I and II. However, they are further 
      activated after exposing to antigens. Recently, several approaches have been 
      exerted to improve antigen presentation potency, to elicit powerful immune 
      responses against tumor cells. In DC-based cancer immunotherapy, DC is obtained 
      from patient and modulated ex vivo in order to entice the immune system toward 
      tumor elimination. Several approaches have been on the evaluation for long-term 
      anti-tumor immune responses by DCs. On the other side, combination of DC vaccines 
      with other cancer therapies, like chemotherapy and monoclonal antibodies could 
      confer efficient cancer therapeutics. In this review article, we first go through 
      the immunobiology of DC, and development of DC vaccines. Then, we concentrate on 
      the DC immunotherapy by highlighting combinational approaches to enhance the 
      efficacy of cancer treatment strategies.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Sadeghzadeh, Mahsa
AU  - Sadeghzadeh M
AD  - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Bornehdeli, Soghra
AU  - Bornehdeli S
AD  - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Mohahammadrezakhani, Haniye
AU  - Mohahammadrezakhani H
AD  - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Abolghasemi, Mahsa
AU  - Abolghasemi M
AD  - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Poursaei, Elham
AU  - Poursaei E
AD  - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Asadi, Milad
AU  - Asadi M
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Zafari, Venus
AU  - Zafari V
AD  - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Aghebati-Maleki, Leili
AU  - Aghebati-Maleki L
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Department of Immunology, School of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran. Electronic address: aghebatil@tbzmed.ac.ir.
FAU - Shanehbandi, Dariush
AU  - Shanehbandi D
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 
      Electronic address: Dariush_shanehbandi@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200320
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Adjuvants, Immunologic)
SB  - IM
MH  - Adjuvants, Immunologic/therapeutic use
MH  - Antigen Presentation/immunology
MH  - Combined Modality Therapy
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immunotherapy
MH  - Neoplasms/immunology/*therapy
MH  - Radiotherapy
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Antigen presenting cells
OT  - Cancer immunotherapy
OT  - Chemotherapy
OT  - Dendritic cells
OT  - Immune system
COIS- Declaration of competing interest None.
EDAT- 2020/03/25 06:00
MHDA- 2020/08/01 06:00
CRDT- 2020/03/25 06:00
PHST- 2019/12/10 00:00 [received]
PHST- 2020/03/14 00:00 [revised]
PHST- 2020/03/19 00:00 [accepted]
PHST- 2020/03/25 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2020/03/25 06:00 [entrez]
AID - S0024-3205(20)30328-3 [pii]
AID - 10.1016/j.lfs.2020.117580 [doi]
PST - ppublish
SO  - Life Sci. 2020 Aug 1;254:117580. doi: 10.1016/j.lfs.2020.117580. Epub 2020 Mar 
      20.