PMID- 32206481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2190-1678 (Print)
IS  - 2190-1686 (Electronic)
IS  - 2190-1678 (Linking)
VI  - 11
IP  - 2
DP  - 2020 Apr
TI  - The effect of long-term past glycemic control on executive function among 
      patients with type 2 diabetes mellitus.
PG  - 114-120
LID - 10.1007/s13340-019-00411-y [doi]
AB  - OBJECTIVE: Patients with type 2 diabetes mellitus (T2DM) show more executive 
      dysfunction than nondiabetics. However, how long poor glycemic control affects 
      executive function remains unclear. Thus, we aimed to investigate the 
      relationships in a cross-sectional study. METHODS: We studied 118 T2DM 
      outpatients (age, >/= 60 years; excluding history of stroke, dementia and severe 
      hypoglycemia). HbA1c values were recorded every </= 12 weeks for >/= 5 years. All 
      patients underwent verbal-fluency tests (reflecting executive function) and 
      Mini-Mental State Examination (MMSE). The correlation between past glycemic 
      control values and both cognitive tests scores was investigated. As markers of 
      past glycemic control, we used average hemoglobin A1c (HbA1c) values and glycemic 
      control variability [coefficient of variation (CV) of HbA1c values (HbA1c-CV)]. 
      RESULTS: Verbal-fluency tests scores correlated with HbA1c-CV, but not with 
      average HbA1c values, after adjusting for age, years of education and sex. 
      Verbal-fluency tests scores correlated with HbA1c-CV for the past 5 years, best 
      compared with HbA1c-CV for past < 5 years. MMSE scores were also related to only 
      HbA1c-CV for the past 3 years in an adjustment model. CONCLUSIONS: Five-year 
      HbA1c variability affected executive function in T2DM patients, but not average 
      HbA1c values. Long-term longitudinal studies may be required.
CI  - (c) The Japan Diabetes Society 2019.
FAU - Minami, Taichi
AU  - Minami T
AD  - 1Division of Metabolism and Endocrinology, Department of Internal Medicine, 
      Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel 
      Mutual Associations, 132 Katsura-cho, Sakae-ku, Yokohama, Japan. GRID: 
      grid.417368.f. ISNI: 0000 0004 0642 0970
AD  - Department of Diabetes and Endocrinology, Saiseikai Yokohamashi Nanbu Hospital, 
      3-2-9 Konandai, Konan-ku, Yokohama, Japan.
AD  - 5Department of Endocrinology and Metabolism, Graduate School of Medicine, 
      Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. GRID: 
      grid.268441.d. ISNI: 0000 0001 1033 6139
FAU - Ito, Yuzuru
AU  - Ito Y
AD  - 5Department of Endocrinology and Metabolism, Graduate School of Medicine, 
      Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. GRID: 
      grid.268441.d. ISNI: 0000 0001 1033 6139
FAU - Yamada, Masayo
AU  - Yamada M
AD  - 1Division of Metabolism and Endocrinology, Department of Internal Medicine, 
      Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel 
      Mutual Associations, 132 Katsura-cho, Sakae-ku, Yokohama, Japan. GRID: 
      grid.417368.f. ISNI: 0000 0004 0642 0970
FAU - Furuta, Ryutaro
AU  - Furuta R
AD  - 2Department of Psychology, Yokohama Sakae Kyosai Hospital, Federation of National 
      Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 
      Yokohama, Japan. GRID: grid.417368.f. ISNI: 0000 0004 0642 0970
FAU - Minagawa, Fuyuki
AU  - Minagawa F
AD  - Minagawa-naika Clinic, 2-14-1 Kasama, Sakae-ku, Yokohama, Japan.
FAU - Kamata, Kentaro
AU  - Kamata K
AD  - 2Department of Psychology, Yokohama Sakae Kyosai Hospital, Federation of National 
      Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 
      Yokohama, Japan. GRID: grid.417368.f. ISNI: 0000 0004 0642 0970
FAU - Kameda, Akiko
AU  - Kameda A
AD  - Department of Diabetes and Endocrinology, Saiseikai Yokohamashi Nanbu Hospital, 
      3-2-9 Konandai, Konan-ku, Yokohama, Japan.
FAU - Terauchi, Yasuo
AU  - Terauchi Y
AUID- ORCID: 0000-0002-8872-3697
AD  - 5Department of Endocrinology and Metabolism, Graduate School of Medicine, 
      Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. GRID: 
      grid.268441.d. ISNI: 0000 0001 1033 6139
LA  - eng
PT  - Journal Article
DEP - 20191003
PL  - Japan
TA  - Diabetol Int
JT  - Diabetology international
JID - 101553224
PMC - PMC7082468
OTO - NOTNLM
OT  - Cognitive dysfunction
OT  - Dementia
OT  - Executive function
OT  - HbA1c variability
OT  - Type 2 diabetes
COIS- Conflict of interestNone of the authors has any potential conflicts of interest 
      associated with this study.
EDAT- 2020/03/25 06:00
MHDA- 2020/03/25 06:01
PMCR- 2020/10/03
CRDT- 2020/03/25 06:00
PHST- 2019/06/14 00:00 [received]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2020/03/25 06:00 [entrez]
PHST- 2020/03/25 06:00 [pubmed]
PHST- 2020/03/25 06:01 [medline]
PHST- 2020/10/03 00:00 [pmc-release]
AID - 411 [pii]
AID - 10.1007/s13340-019-00411-y [doi]
PST - epublish
SO  - Diabetol Int. 2019 Oct 3;11(2):114-120. doi: 10.1007/s13340-019-00411-y. 
      eCollection 2020 Apr.