PMID- 32208803
OWN - NLM
STAT- MEDLINE
DCOM- 20210219
LR  - 20210820
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 40
IP  - 7
DP  - 2020 Jul
TI  - Multifaceted roles of pericytes in central nervous system homeostasis and 
      disease.
PG  - 1381-1401
LID - 10.1177/0271678X20911331 [doi]
AB  - Pericytes, the mural cells surrounding microcirculation, are gaining increasing 
      attention for their roles in health and disease of the central nervous system 
      (CNS). As an essential part of the neurovascular unit (NVU), pericytes are 
      actively engaged in interactions with neighboring cells and work in synergy with 
      them to maintain homeostasis of the CNS, such as maintaining the blood-brain 
      barrier (BBB), regulating cerebral blood flow (CBF) and the glymphatic system as 
      well as mediating immune responses. However, the dysfunction of pericytes may 
      contribute to the progression of various pathologies. In this review, we discuss: 
      (1) origin of pericytes and different pericyte markers; (2) interactions of 
      pericytes with endothelial cells (ECs), astrocytes, microglia, oligodendrocytes, 
      and neurons; (3) physiological roles of pericytes in the CNS; (4) effects of 
      pericytes in different CNS diseases; (5) relationship of pericytes with 
      extracellular vesicles (EVs) and microRNAs (miRs); (6) recent advances in 
      pericytes studies and future perspective.
FAU - Zheng, Zhitong
AU  - Zheng Z
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
FAU - Chopp, Michael
AU  - Chopp M
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
AD  - Department of Physics, Oakland University, Rochester, MI, USA.
FAU - Chen, Jieli
AU  - Chen J
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
LA  - eng
GR  - R01 HL143432/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20200324
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Animals
MH  - Central Nervous System Diseases/*pathology/*physiopathology
MH  - Homeostasis/*physiology
MH  - Humans
MH  - Pericytes/*pathology/*physiology
PMC - PMC7308511
OTO - NOTNLM
OT  - Pericyte
OT  - central nervous system disease
OT  - extracellular vesicles
OT  - glymphatic system
OT  - microRNA
EDAT- 2020/03/27 06:00
MHDA- 2021/02/20 06:00
PMCR- 2021/03/24
CRDT- 2020/03/27 06:00
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/03/27 06:00 [entrez]
PHST- 2021/03/24 00:00 [pmc-release]
AID - 10.1177_0271678X20911331 [pii]
AID - 10.1177/0271678X20911331 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2020 Jul;40(7):1381-1401. doi: 
      10.1177/0271678X20911331. Epub 2020 Mar 24.