PMID- 32209448
OWN - NLM
STAT- MEDLINE
DCOM- 20210611
LR  - 20210611
IS  - 2405-8025 (Electronic)
IS  - 2405-8025 (Linking)
VI  - 6
IP  - 4
DP  - 2020 Apr
TI  - Gap Junctions and Breast Cancer Dormancy.
PG  - 348-357
LID - S2405-8033(20)30029-7 [pii]
LID - 10.1016/j.trecan.2020.01.013 [doi]
AB  - Breast cancer (BC) relapse, despite clinical advancement, remains one of the 
      biggest issues in the field. Intercellular communication, specifically via 
      connexin (Cx)-mediated gap junctions (GJs), play a key role in the long-term 
      survival of these, treatment-resistant breast cancer stem cells (CSCs), allowing 
      for relapse. Both basic and clinical evidence reveal dual roles for GJs, in tumor 
      suppression, generally referred to as dormancy, and progression and metastasis. 
      GJ intercellular communication (GJIC) can be mediated by multiple types of Cxs, 
      depending on the organ to which the BC cells metastasize. This review expands on 
      the differential expression of Cx-mediated GJIC between CSCs and niche cells 
      within a given microenvironment.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Sinha, Garima
AU  - Sinha G
AD  - Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA; 
      Department of Medicine - Hematology/Oncology, Rutgers New Jersey Medical School, 
      Newark, NJ, USA.
FAU - Ferrer, Alejandra I
AU  - Ferrer AI
AD  - Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA; 
      Department of Medicine - Hematology/Oncology, Rutgers New Jersey Medical School, 
      Newark, NJ, USA.
FAU - Moore, Caitlyn A
AU  - Moore CA
AD  - Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA; 
      Department of Medicine - Hematology/Oncology, Rutgers New Jersey Medical School, 
      Newark, NJ, USA.
FAU - Naaldijk, Yahaira
AU  - Naaldijk Y
AD  - Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA.
FAU - Rameshwar, Pranela
AU  - Rameshwar P
AD  - Department of Medicine - Hematology/Oncology, Rutgers New Jersey Medical School, 
      Newark, NJ, USA. Electronic address: rameshwa@njms.rutgers.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200220
PL  - United States
TA  - Trends Cancer
JT  - Trends in cancer
JID - 101665956
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Connexins)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - Autophagy/drug effects/immunology
MH  - Breast/growth & development/pathology
MH  - Breast Neoplasms/drug therapy/immunology/*pathology
MH  - Cell Communication/drug effects/immunology
MH  - Connexins/antagonists & inhibitors/drug effects/immunology/*metabolism
MH  - Disease Models, Animal
MH  - Drug Resistance, Neoplasm/drug effects/immunology
MH  - Female
MH  - Gap Junctions/drug effects/immunology/*pathology
MH  - Humans
MH  - Mammary Glands, Animal/growth & development/pathology
MH  - Mice
MH  - Neoplasm Recurrence, Local/immunology/*pathology/prevention & control
MH  - Neoplastic Stem Cells/pathology
MH  - Tumor Escape/drug effects
MH  - Tumor Microenvironment/drug effects/immunology
OTO - NOTNLM
OT  - bone marrow
OT  - breast cancer
OT  - connexin
OT  - dormancy
OT  - gap junction
OT  - metastasis
EDAT- 2020/03/27 06:00
MHDA- 2021/06/12 06:00
CRDT- 2020/03/27 06:00
PHST- 2019/06/03 00:00 [received]
PHST- 2020/01/22 00:00 [revised]
PHST- 2020/01/23 00:00 [accepted]
PHST- 2020/03/27 06:00 [entrez]
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/06/12 06:00 [medline]
AID - S2405-8033(20)30029-7 [pii]
AID - 10.1016/j.trecan.2020.01.013 [doi]
PST - ppublish
SO  - Trends Cancer. 2020 Apr;6(4):348-357. doi: 10.1016/j.trecan.2020.01.013. Epub 
      2020 Feb 20.