PMID- 32209872
OWN - NLM
STAT- MEDLINE
DCOM- 20210324
LR  - 20210324
IS  - 2162-5220 (Electronic)
IS  - 1710-3568 (Linking)
VI  - 31
IP  - 3
DP  - 2020 May/Jun
TI  - Nasal Colonization by Staphylococci and Severity of Atopic Dermatitis.
PG  - 215-222
LID - 10.1097/DER.0000000000000568 [doi]
AB  - BACKGROUND: Skin colonization by Staphylococcus aureus (SA) correlates with 
      increased severity of atopic dermatitis (AD). The role of nasal SA carriage and 
      coagulase-negative staphylococci (CNSs) in AD is unclear. OBJECTIVE: The aim of 
      this study was to assess the influence of colonization of lesional/nonlesional 
      skin and the anterior nares by SA and CNSs on AD severity in 63 adult patients. 
      METHODS: Disease severity was assessed with SCORAD index. The total 
      immunoglobulin E (IgE) concentration was determined using the enzyme-linked 
      immunosorbent assay method. The prevalence and abundance of staphylococci were 
      assessed with the combination of bacterial culture and mass spectrometry. 
      RESULTS: The prevalence values of SA within the skin (lesional/nonlesional) and 
      anterior nares were 79.4%/61.9% and 69.8%, respectively (vs 5.6% and 13.9%, 
      respectively in controls, P < 0.0001). The carriage of CNSs in all niches was 
      associated with lower mean IgE concentration (1164.66 +/- 1010.36 vs 1762.99 +/- 
      1059.15, P < 0.0213; 1166.9 +/- 1006.4 vs 2152.7 +/- 759.2, P < 0.0063; 1022 +/- 1100 
      vs 1925 +/- 880.8, P < 0.0044, respectively). The abundance of SA correlated with 
      the extent of skin lesions and total IgE (rho = 0.42, P = 0.0007; rho = 0.488, P < 
      0.0001; rho = 0.312, P < 0.2; and rho = 0.402, P = 0.0007; rho = 0.403, P < 0.002; rho = 
      0.287, P < 0.03, respectively). CONCLUSIONS: Atopic dermatitis severity 
      correlates with both cutaneous and nasal colonization by SA. Staphylococcus 
      aureus seems to promote TH2-type response, whereas CNS probably limits this 
      process. Preventive measures within the anterior nares should be considered for 
      AD patients.
FAU - Blicharz, Leszek
AU  - Blicharz L
AD  - From the Departments of Dermatology.
FAU - Usarek, Paulina
AU  - Usarek P
AD  - Medical Microbiology, Medical University of Warsaw.
FAU - Mlynarczyk, Grazyna
AU  - Mlynarczyk G
AD  - Medical Microbiology, Medical University of Warsaw.
FAU - Skowronski, Krzysztof
AU  - Skowronski K
AD  - Applied Analytics Group, iQor, Warsaw, Poland.
FAU - Rudnicka, Lidia
AU  - Rudnicka L
AD  - From the Departments of Dermatology.
FAU - Samochocki, Zbigniew
AU  - Samochocki Z
AD  - From the Departments of Dermatology.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dermatitis
JT  - Dermatitis : contact, atopic, occupational, drug
JID - 101207335
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Asymptomatic Infections
MH  - *Bacterial Load
MH  - Dermatitis, Atopic/immunology/*physiopathology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Middle Aged
MH  - Nasal Mucosa/*microbiology
MH  - Poland
MH  - Severity of Illness Index
MH  - Staphylococcus/immunology/isolation & purification
MH  - Staphylococcus aureus/immunology/*isolation & purification
MH  - Young Adult
EDAT- 2020/03/27 06:00
MHDA- 2021/03/25 06:00
CRDT- 2020/03/27 06:00
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/03/25 06:00 [medline]
PHST- 2020/03/27 06:00 [entrez]
AID - 10.1097/DER.0000000000000568 [doi]
PST - ppublish
SO  - Dermatitis. 2020 May/Jun;31(3):215-222. doi: 10.1097/DER.0000000000000568.