PMID- 32210218
OWN - NLM
STAT- MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 78
IP  - 5
DP  - 2020 May 25
TI  - Relationship among the leptin-to-adiponectin ratio, systemic inflammation, and 
      anisocytosis in well-controlled type 2 diabetic patients with atherosclerotic 
      cardiovascular disease.
PG  - 420-428
LID - 10.33963/KP.15257 [doi]
AB  - BACKGROUND: Previous studies have shown that red blood cell distribution width 
      (RDW) is an independent predictor of poor prognosis in type 2 diabetes (T2D) and 
      atherosclerotic cardiovascular disease (ASCVD). The mechanisms underlying 
      increased anisocytosis in patients with T2D and confirmed ASCVD remain poorly 
      understood. AIMS: We sought to evaluate the relationship among the 
      leptin-to-adiponectin ratio, systemic low -grade inflammation, and RDW in 
      optimally treated patients with T2D and established ASCVD. METHODS: A total of 68 
      patients, aged 47 to 85 years (mean [SD], 65.3 [6.8] years) and including 21 
      women (30.9%), were enrolled and grouped according to median RDW into those with 
      RDW <13.5% (n = 33) and those with RDW >/=13.5% (n = 35). RESULTS: Patients with 
      RDW >/=13.5% had a significantly higher median (interquartile range [IQR]) serum 
      leptin-to-adiponectin ratio (1.7 [0.49-2.3] ng/mug vs 0.66 [0.31-1.25] ng/mug; P = 
      0.04) and median (IQR) tumor necrosis factor alpha levels (1.58 [1.42-1.97] pg/ml vs 
      1.39 [1.18-1.57] pg/ml; P = 0.02). There were no significant differences in the 
      concentrations of other inflammatory markers. The leptin-to-adiponectin ratio (r 
      = 0.25; P = 0.04) and levels of tumor necrosis factor alpha (r = 0.32; P = 0.01) and 
      soluble intercellular adhesion molecule 1 (r = 0.31; P = 0.01) were positively 
      correlated with RDW, which was confirmed by univariate linear regression 
      analysis. A multivariable regression model, which included demographic, clinical, 
      and laboratory data, showed that white blood cell count (beta = 0.25; 95% CI, 
      0.05-0.45; P = 0.01), soluble intercellular adhesion molecule 1 levels (beta = 0.21; 
      95% CI, 0.02-0.41; P = 0.03), and mean corpuscular hemoglobin concentration 
      (MCHC), (beta = -0.48; 95% CI, 0.67 to -0.28; P < 0.001) were independent predictors 
      of RDW in our patients. CONCLUSIONS: In well-controlled patients with T2D and 
      ASCVD, the RDW values are associated with leptin-to-adiponectin imbalance and 
      selected inflammatory markers.
FAU - Rostoff, Pawel
AU  - Rostoff P
AD  - Department of Coronary Disease and Heart Failure, Institute of Cardiology, 
      Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
FAU - Siniarski, Aleksander
AU  - Siniarski A
AD  - Department of Coronary Disease and Heart Failure, Institute of Cardiology, 
      Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
FAU - Haberka, Maciej
AU  - Haberka M
AD  - Department of Cardiology, School of Health Sciences, Medical University of 
      Silesia, Katowice, Poland
FAU - Konduracka, Ewa
AU  - Konduracka E
AD  - Department of Coronary Disease and Heart Failure, Institute of Cardiology, 
      Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
FAU - Nessler, Jadwiga
AU  - Nessler J
AD  - Department of Coronary Disease and Heart Failure, Institute of Cardiology, 
      Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
FAU - Gajos, Grzegorz
AU  - Gajos G
AD  - Department of Coronary Disease and Heart Failure, Institute of Cardiology, 
      Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland. 
      grzegorz.gajos@uj.edu.pl
LA  - eng
PT  - Journal Article
DEP - 20200324
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
SB  - IM
CIN - Kardiol Pol. 2020 May 25;78(5):381-382. PMID: 32458664
MH  - Adiponectin
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiovascular Diseases/etiology
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Inflammation/etiology
MH  - Leptin
MH  - Male
MH  - Middle Aged
EDAT- 2020/03/27 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/03/27 06:00
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/03/27 06:00 [entrez]
AID - 10.33963/KP.15257 [doi]
PST - ppublish
SO  - Kardiol Pol. 2020 May 25;78(5):420-428. doi: 10.33963/KP.15257. Epub 2020 Mar 24.