PMID- 32211038
OWN - NLM
STAT- MEDLINE
DCOM- 20210407
LR  - 20210407
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2020
DP  - 2020
TI  - The Reorganization of Insular Subregions in Individuals with Below-Level 
      Neuropathic Pain following Incomplete Spinal Cord Injury.
PG  - 2796571
LID - 10.1155/2020/2796571 [doi]
LID - 2796571
AB  - OBJECTIVE: To investigate the reorganization of insular subregions in individuals 
      suffering from neuropathic pain (NP) after incomplete spinal cord injury (ISCI) 
      and further to disclose the underlying mechanism of NP. METHOD: The 3D 
      high-resolution T1-weighted structural images and resting-state functional 
      magnetic resonance imaging (rs-fMRI) of all individuals were obtained using a 3.0 
      Tesla MRI system. A comparative analysis of structure and function connectivity 
      (FC) with insular subareas as seeds in 10 ISCI individuals with below-level NP 
      (ISCI-P), 11 ISCI individuals without NP (ISCI-N), and 25 healthy controls (HCs) 
      was conducted. Associations between the structural and functional alteration of 
      insula subregions and visual analog scale (VAS) scores were analyzed using the 
      Pearson correlation in SPSS 20. RESULTS: Compared with ISCI-N patients, when the 
      left posterior insula as the seed, ISCI-P showed increased FC in right cerebellum 
      VIIb and cerebellum VIII, Brodmann 37 (BA 37). When the left ventral anterior 
      insula as the seed, ISCI-P indicated enhanced FC in right BA18 compared with 
      ISCI-N patients. These increased FCs positively correlated with VAS scores. 
      Relative to HCs, ISCI-P presented increased FC in the left hippocampus when the 
      left dorsal anterior insula was determined as the seed. There was no statistical 
      difference in the volume of insula subregions among the three groups. CONCLUSION: 
      Our study indicated that distinctive patterns of FC in each subregion of insula 
      suggest that the insular subareas participate in the NP processing through 
      different FC following ISCI. Further, insula subregions could serve as a 
      therapeutic target for NP following ISCI.
CI  - Copyright (c) 2020 Xuejing Li et al.
FAU - Li, Xuejing
AU  - Li X
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, 100053, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      100053, China.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, 100053, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      100053, China.
FAU - Chen, Qian
AU  - Chen Q
AUID- ORCID: 0000-0001-5210-9647
AD  - Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 
      100050, China.
FAU - Hu, Yongsheng
AU  - Hu Y
AD  - Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical 
      University, 100053, China.
FAU - Du, Jubao
AU  - Du J
AD  - Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical 
      University, 100053, China.
FAU - Chen, Xin
AU  - Chen X
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, 100053, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      100053, China.
FAU - Zheng, Weimin
AU  - Zheng W
AUID- ORCID: 0000-0002-3410-6773
AD  - Department of Radiology, Aerospace Central Hospital, 100049, China.
FAU - Lu, Jie
AU  - Lu J
AUID- ORCID: 0000-0003-0425-3921
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, 100053, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      100053, China.
FAU - Chen, Nan
AU  - Chen N
AUID- ORCID: 0000-0001-8210-103X
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, 100053, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      100053, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200310
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Mapping
MH  - Cerebral Cortex/diagnostic imaging/*pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/pathology/physiopathology
MH  - Neuralgia/etiology/*pathology/*physiopathology
MH  - Spinal Cord Injuries/*complications
MH  - Young Adult
PMC - PMC7085828
COIS- The authors declare that they have no conflict of interests.
EDAT- 2020/03/27 06:00
MHDA- 2021/04/10 06:00
PMCR- 2020/03/10
CRDT- 2020/03/27 06:00
PHST- 2019/12/03 00:00 [received]
PHST- 2020/02/06 00:00 [revised]
PHST- 2020/02/11 00:00 [accepted]
PHST- 2020/03/27 06:00 [entrez]
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/03/10 00:00 [pmc-release]
AID - 10.1155/2020/2796571 [doi]
PST - epublish
SO  - Neural Plast. 2020 Mar 10;2020:2796571. doi: 10.1155/2020/2796571. eCollection 
      2020.