PMID- 3221156
OWN - NLM
STAT- MEDLINE
DCOM- 19890317
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 119
IP  - 3
DP  - 1988 Dec
TI  - Precopulatory behaviour in the male hamster: effect of the 5 alpha-reductase 
      inhibitor 17 beta-N,N-diethylcarbamoyl-4-aza-5 alpha-androstan-3-one.
PG  - 483-91
AB  - Three independent components of hamster masculine behaviour (approaching, leaving 
      and sniffing the female) have been shown to depend on both androgenic and 
      oestrogenic action. The behavioural role of 5 alpha-reduced androgens was 
      assessed by blocking 5 alpha-reduction of testosterone by means of 17 
      beta-N,N-diethylcarbamoyl-4-aza-5 alpha-androstan-3-one (4-MA) through 
      slow-release silicone elastomer implants. Three dose levels of 4-MA were given to 
      intact, sexually active males. The probability of approaching the female and the 
      amount of sniffing directed to her were both decreased, while the probability of 
      leaving the female was increased. Sniffing and the tendency to approach were 
      affected at lower dose levels than was the tendency to leave. The higher dosage 
      of 4-MA also abolished odour-based discrimination between females shown by normal 
      males. These effects of 4-MA on behaviour were confirmed in castrated hamsters 
      maintained on testosterone. The suppressive effects of 4-MA on behaviour were 
      reversed by treatment with 5 alpha-dihydrotestosterone (DHT). We conclude that 
      testosterone maintains sociosexual behaviour in part by conversion to its 5 
      alpha-reduced metabolites; components of this behaviour differ in their relative 
      dependence on DHT. In this species, DHT is likely to be a behaviourally active 
      metabolite of testosterone involved in the fine control of behaviour.
FAU - Steel, E
AU  - Steel E
AD  - MRC Unit on the Development and Integration of Behaviour, University of 
      Cambridge, Madingley.
FAU - Hutchison, J B
AU  - Hutchison JB
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Androgen Antagonists)
RN  - 0 (Azasteroids)
RN  - 0 (Steroids, Heterocyclic)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 3XMK78S47O (Testosterone)
RN  - 73671-86-0 (17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one)
SB  - IM
MH  - Androgen Antagonists/*pharmacology
MH  - Animals
MH  - Azasteroids/*pharmacology
MH  - Copulation/drug effects
MH  - Cricetinae
MH  - Dihydrotestosterone/*analogs & derivatives/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Orchiectomy
MH  - Sexual Behavior, Animal/*drug effects
MH  - Smell/physiology
MH  - Steroids, Heterocyclic/*pharmacology
MH  - Testosterone/pharmacology
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 10.1677/joe.0.1190483 [doi]
PST - ppublish
SO  - J Endocrinol. 1988 Dec;119(3):483-91. doi: 10.1677/joe.0.1190483.