PMID- 32211780
OWN - NLM
STAT- MEDLINE
DCOM- 20210211
LR  - 20210211
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 59
IP  - 11
DP  - 2020 Nov 1
TI  - Biomarker panels may be superior over single molecules in prediction of renal 
      flares in systemic lupus erythematosus: an exploratory study.
PG  - 3193-3200
LID - 10.1093/rheumatology/keaa074 [doi]
AB  - OBJECTIVE: Recent evidence suggests that some urinary biomarkers, namely Vascular 
      Cell Adhesion Molecule-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1), 
      Monocyte Chemoattractant Protein 1 (MCP-1), Neutrophil Gelatinase Associated 
      Lipocalcin and Lipocalin-type Prostaglandin D-Synthetase (L-PGDS), might 
      discriminate SLE patients with ongoing renal activity from those with stable 
      disease. The objective of this study was to assess the role of these markers in 
      predicting renal flares in comparison with conventional biomarkers and to derive 
      a biomarker panel which may improve diagnostic accuracy. METHODS: Eligible 
      participants were SLE patients prospectively followed at our clinic. Urinary 
      biomarker levels were measured in urinary sample by ELISA assay and were compared 
      by the unpaired Student's t test or the Mann-Whitney U test as appropriate. 
      Receiver operating characteristic analysis was used to calculate the area under 
      the curve. Cox regression was used to identify independent factors associated 
      with disease flares. RESULTS: Urine was collected from 61 patients. During 
      8 months' follow-up, eight patients experienced a renal flare. Urinary L-PGDS, 
      ICAM-1 and VCAM-1 levels were significantly increased in the patients who 
      subsequently experienced a renal flare with respect to the remaining 53. At Cox 
      regression analysis, L-PGDS, ICAM-1, VCAM-1, hypocomplementemia and anti-dsDNA 
      antibodies were factors associated with renal flares. Based on receiver operating 
      characteristic analysis, a combination of novel and conventional biomarkers 
      demonstrated an excellent ability for accurately identifying a flare. CONCLUSION: 
      This study might suggest the usefulness of a novel biomarker panel in predicting 
      a renal flare in SLE.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Fasano, Serena
AU  - Fasano S
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Pierro, Luciana
AU  - Pierro L
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Borgia, Alessia
AU  - Borgia A
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Coscia, Melania Alessia
AU  - Coscia MA
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Formica, Ranieri
AU  - Formica R
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Bucci, Laura
AU  - Bucci L
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Riccardi, Antonella
AU  - Riccardi A
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
FAU - Ciccia, Francesco
AU  - Ciccia F
AD  - Rheumatology Section, Department of Precision Medicine, University of Campania L. 
      Vanvitelli, Naples, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/urine
MH  - Female
MH  - Humans
MH  - Kidney Diseases/*etiology/*urine
MH  - Lupus Erythematosus, Systemic/*complications/*urine
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
OTO - NOTNLM
OT  - biomarkers
OT  - lupus nephritis
OT  - systemic lupus erythematosus
EDAT- 2020/03/27 06:00
MHDA- 2021/02/12 06:00
CRDT- 2020/03/27 06:00
PHST- 2019/09/24 00:00 [received]
PHST- 2020/01/27 00:00 [revised]
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/02/12 06:00 [medline]
PHST- 2020/03/27 06:00 [entrez]
AID - 5811390 [pii]
AID - 10.1093/rheumatology/keaa074 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2020 Nov 1;59(11):3193-3200. doi: 
      10.1093/rheumatology/keaa074.