PMID- 32212364
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 42
IP  - 8
DP  - 2020 Aug
TI  - Biological tumor markers (maspin, CD105, nm23-H1) and disease relapse in 
      laryngeal cancer: cluster analysis.
PG  - 2129-2136
LID - 10.1002/hed.26152 [doi]
AB  - BACKGROUND: The aim of this investigation was to see if a panel of biomarkers 
      (maspin, CD105, and nm23-H1) could be used to stratify patients with laryngeal 
      squamous cell carcinoma (LSCC) in homogeneous disease recurrence risk clusters. 
      METHODS: Cluster analysis was used to classify 89 patients based on their 
      immunohistochemical expression of nm23-H1, CD105, and maspin. RESULTS: Our 
      analysis identified seven homogeneous clusters: the LSCC recurrence rate was 
      lowest in cluster 6 (non-nuclear maspin pattern, nuclear nm23-H1 expression >/=10%, 
      endothelial CD105 expression <6%; P = .009), and highest in cluster 3 
      (non-nuclear maspin pattern, nuclear nm23-H1 expression <10%, endothelial CD105 
      expression >/=6%; P <.001). CONCLUSIONS: Similar panels of biological variables 
      identified by cluster analysis should be tested in prospective clinical trials to 
      establish whether treating patients identified as being at higher risk of LSCC 
      recurrence more aggressively could significantly improve their recurrence rate 
      and/or disease-specific survival.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Franz, Leonardo
AU  - Franz L
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Tealdo, Giulia
AU  - Tealdo G
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Contro, Giacomo
AU  - Contro G
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Bandolin, Luigia
AU  - Bandolin L
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Carraro, Valentina
AU  - Carraro V
AD  - Department of Medicine DIMED, University of Padova, Padova, Italy.
FAU - Giacomelli, Luciano
AU  - Giacomelli L
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Alessandrini, Lara
AU  - Alessandrini L
AD  - Department of Medicine DIMED, University of Padova, Padova, Italy.
FAU - Blandamura, Stella
AU  - Blandamura S
AD  - Department of Medicine DIMED, University of Padova, Padova, Italy.
FAU - Marioni, Gino
AU  - Marioni G
AUID- ORCID: 0000-0001-8751-0588
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200325
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - 0 (SERPIN-B5)
RN  - 0 (Serpins)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Cluster Analysis
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/therapy
MH  - NM23 Nucleoside Diphosphate Kinases/genetics
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Prospective Studies
MH  - Serpins
OTO - NOTNLM
OT  - CD105
OT  - cluster analysis
OT  - laryngeal squamous cell carcinoma
OT  - maspin
OT  - nm23-H1
OT  - prognosis
OT  - recurrence rate
EDAT- 2020/03/27 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/03/27 06:00
PHST- 2019/11/15 00:00 [received]
PHST- 2020/01/06 00:00 [revised]
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/03/27 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/03/27 06:00 [entrez]
AID - 10.1002/hed.26152 [doi]
PST - ppublish
SO  - Head Neck. 2020 Aug;42(8):2129-2136. doi: 10.1002/hed.26152. Epub 2020 Mar 25.