PMID- 32212695
OWN - NLM
STAT- MEDLINE
DCOM- 20200715
LR  - 20200715
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 9
DP  - 2020 May 5
TI  - Environmental Pollutants Modulate Transcriptional Activity of Nuclear Receptors 
      of Whales In Vitro.
PG  - 5629-5639
LID - 10.1021/acs.est.9b06952 [doi]
AB  - This study reports the transcriptional activity of fin (Balaenoptera physalus) 
      and blue whale (Balaenoptera musculus) peroxisome proliferator-activated receptor 
      gamma (PPARG), glucocorticoid receptor (GR), and thyroid hormone receptor beta (THRB), 
      when exposed to 14 persistent organic pollutants (so-called "legacy" persistent 
      organic pollutants (POPs)) and a synthetic mixture of POPs, using GAL4-UAS-based 
      in vitro luciferase reporter gene assays. Polychlorinated biphenyls (PCBs) had 
      both agonistic and antagonistic effects on PPARG and GR, and mainly antagonistic, 
      except for PCB153, effects on THRB. 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane 
      (DDT) and its metabolites had mainly antagonistic effects on all of the 
      receptors, except for o,p'-DDT. Given that the ligand-binding domain (LBD) of 
      PPARG is the same in killer whales, white whales, polar bears, and humans, and 
      that GR-LBD is identical in killer whales and minke whales and that the LBD of 
      THRB is the same in killer whales, white whales, and humans, it is likely that 
      the results of this study are representative for these other species as well. It 
      is important to note that several environmental pollutants modulated the 
      transcriptional activity of tested nuclear receptors at environmentally relevant 
      concentrations for whales.
FAU - Luhmann, Katharina
AU  - Luhmann K
AUID- ORCID: 0000-0002-4179-480X
AD  - Norwegian Polar Institute, Fram Centre, Tromso 9296, Norway.
AD  - Institute for Environmental Sciences, University Koblenz-Landau, Landau in der 
      Pfalz 76829, Germany.
FAU - Lille-Langoy, Roger
AU  - Lille-Langoy R
AD  - Department of Biological Sciences, University of Bergen, Bergen 5020, Norway.
FAU - Oygarden, Lene
AU  - Oygarden L
AD  - Department of Biological Sciences, University of Bergen, Bergen 5020, Norway.
FAU - Kovacs, Kit M
AU  - Kovacs KM
AD  - Norwegian Polar Institute, Fram Centre, Tromso 9296, Norway.
FAU - Lydersen, Christian
AU  - Lydersen C
AD  - Norwegian Polar Institute, Fram Centre, Tromso 9296, Norway.
FAU - Goksoyr, Anders
AU  - Goksoyr A
AD  - Department of Biological Sciences, University of Bergen, Bergen 5020, Norway.
FAU - Routti, Heli
AU  - Routti H
AUID- ORCID: 0000-0001-5560-888X
AD  - Norwegian Polar Institute, Fram Centre, Tromso 9296, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200413
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*analysis
MH  - *Fin Whale
MH  - Humans
MH  - Polychlorinated Biphenyls/*analysis
MH  - Receptors, Cytoplasmic and Nuclear
MH  - Water Pollutants, Chemical/*analysis
EDAT- 2020/03/28 06:00
MHDA- 2020/07/16 06:00
CRDT- 2020/03/28 06:00
PHST- 2020/03/28 06:00 [pubmed]
PHST- 2020/07/16 06:00 [medline]
PHST- 2020/03/28 06:00 [entrez]
AID - 10.1021/acs.est.9b06952 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 May 5;54(9):5629-5639. doi: 10.1021/acs.est.9b06952. 
      Epub 2020 Apr 13.