PMID- 32212788
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200903
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Print)
IS  - 1513-7368 (Linking)
VI  - 21
IP  - 3
DP  - 2020 Mar 1
TI  - Chromosomal Abnormalities in Myelodysplastic Syndrome Patients in Upper Northern 
      Thailand.
PG  - 639-645
LID - 88995 [pii]
LID - 10.31557/APJCP.2020.21.3.639 [doi]
AB  - OBJECTIVE: Chromosome detection is important in the diagnosis and prognosis of 
      Myelodysplastic syndrome (MDS) patients. About 50% of MDS patients have 
      chromosomal abnormalities. Moreover, chromosome 5 and 7 are common genetic 
      abnormalities in MDS patients and use to identify prognosis risk group and the 
      proper treatment in MDS patients. The objective of this study was to evaluate 
      chromosomal abnormalities and clinical features of MDS patients in upper northern 
      Thailand. METHODS: Fifty bone marrow (BM) specimens were examined by conventional 
      cytogenetic (CC) technique and fluorescence in situ hybridization (FISH) 
      technique for detected chromosome 5 and 7 abnormalities. The clinical features 
      were comparison between MDS patients with chromosomal abnormalities and those 
      with normal karyotype. RESULTS: Chromosomal abnormalities were detected in 8/50 
      MDS patients by CC and 17/50 cases by FISH technique. When the CC and FISH 
      techniques were combined, chromosomal abnormalities increased to 21/50 cases.  
      Abnormalities of isolated chromosome 5 were found in 13 cases and were associated 
      with lower level of percentage blast of BM (p = 0.003) and higher level of 
      hemoglobin (p = 0.019). Moreover, abnormalities of chromosome 7 were found in 3 
      cases, 1 case of isolated del(7q) and 2 cases of -7 and del(7q) with complex 
      abnormalities. These three cases were associated with higher level of percentage 
      blast of BM (p = 0.010). CONCLUSION: This study showed the frequency and pattern 
      of chromosomal abnormalities of MDS patients in upper northern Thailand were 
      different from other populations. MDS with isolated chromosome 5 abnormalities 
      had clinical characteristics corresponding with patients in good prognosis risk 
      group. However, MDS patients with chromosome 7 and complex abnormalities showed 
      higher percentage blast of BM which high risk to progression to acute myeloid 
      leukemia (AML). Combined CC and FISH techniques detect chromosomal abnormalities 
      with greater frequency than when either technique is used alone.<br />.
FAU - Phrommin, Suphitcha
AU  - Phrommin S
AD  - Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Tantiworawit, Adisak
AU  - Tantiworawit A
AD  - Division of Hematology, Department of Internal Medicine, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
FAU - Rattanathammethee, Thanawat
AU  - Rattanathammethee T
AD  - Division of Hematology, Department of Internal Medicine, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
FAU - Puaninta, Chaniporn
AU  - Puaninta C
AD  - Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Pangjaidee, Nathaporn
AU  - Pangjaidee N
AD  - Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Aungsuchawan, Sirinda
AU  - Aungsuchawan S
AD  - Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Bumroongkit, Kanokkan
AU  - Bumroongkit K
AD  - Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
LA  - eng
PT  - Journal Article
DEP - 20200301
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 5
MH  - Chromosomes, Human, Pair 7
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Thailand
PMC - PMC7437337
OTO - NOTNLM
OT  - Chromosomal abnormalities
OT  - Fluorescence in Situ Hybridization
OT  - Myelodysplastic syndrome
OT  - conventional cytogenetic technique
OT  - upper Northern Thailand
EDAT- 2020/03/28 06:00
MHDA- 2020/04/03 06:00
PMCR- 2020/05/01
CRDT- 2020/03/28 06:00
PHST- 2019/09/02 00:00 [received]
PHST- 2020/03/28 06:00 [entrez]
PHST- 2020/03/28 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - 88995 [pii]
AID - 10.31557/APJCP.2020.21.3.639 [doi]
PST - epublish
SO  - Asian Pac J Cancer Prev. 2020 Mar 1;21(3):639-645. doi: 
      10.31557/APJCP.2020.21.3.639.