PMID- 32213226
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
DP  - 2020 Mar 26
TI  - Prevalence of vitamin D deficiency in urban south Indians with different grades 
      of glucose tolerance.
PG  - 1-8
LID - 10.1017/S0007114520001129 [doi]
AB  - The present study assessed the prevalence of vitamin D deficiency in an urban 
      south Indian population in individuals with different grades of glucose 
      tolerance. A total of 1500 individuals (900 normal glucose tolerance (NGT), 300 
      prediabetes and 300 with type 2 diabetes mellitus (T2DM)) who were not on vitamin 
      D supplementation were randomly selected from the Chennai Urban Rural 
      Epidemiological Study follow-up study. Anthropometric, clinical examination and 
      biochemical investigations (25-hydroxyvitamin D (25(OH)D), insulin, glycated Hb 
      (HbA1c) and serum lipids) were measured. Vitamin D deficiency was defined as 
      serum 25(OH)D < 20.0 ng/ml, insufficiency as 20-29.9 ng/ml and sufficiency as >/=30 
      ng/ml. Of the 1500 individuals studied, 45 % were males and the mean age was 46 
      (sd 12) years. Vitamin D levels lowered with increasing degrees of glucose 
      tolerance (NGT: 21 (sd 11); prediabetes: 19 (sd 10); T2DM: 18 (sd 11) ng/ml, P < 
      0.001). The overall prevalence of vitamin D deficiency was 55 % and was 
      significantly higher among individuals with T2DM (63 %) followed by prediabetes 
      (58 %) and NGT (51 %) (Pfor trend < 0.001). Women had 1.6 times the risk of 
      vitamin D deficiency compared with men (unadjusted OR 1.6 (95 % CI 1.3, 2.0) and 
      adjusted OR 1.6 (95 % CI 1.2, 1.9)). However, there was no increasing trend 
      observed with increasing age. The prevalence of abdominal obesity (66 v. 49 %), 
      generalised obesity (80 v. 64 %), the metabolic syndrome (45 v. 37 %) and insulin 
      resistance (38 v. 27 %) was significantly higher in those with vitamin D 
      deficiency compared with those without. This study shows that vitamin D 
      deficiency is highly prevalent in this urban south Indian population and was 
      higher among individuals with T2DM and prediabetes compared with those with NGT.
FAU - Jayashri, Ramamoorthy
AU  - Jayashri R
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
FAU - Venkatesan, Ulagamathesan
AU  - Venkatesan U
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
FAU - Shanthirani, Coimbatore S
AU  - Shanthirani CS
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
FAU - Deepa, Mohan
AU  - Deepa M
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
FAU - Anjana, Ranjit Mohan
AU  - Anjana RM
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
FAU - Mohan, Viswanathan
AU  - Mohan V
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
FAU - Pradeepa, Rajendra
AU  - Pradeepa R
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and 
      ICMR Centre for Advanced Research on Diabetes, Chennai, India.
LA  - eng
PT  - Journal Article
DEP - 20200326
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
SB  - IM
OTO - NOTNLM
OT  - Diabetes
OT  - Glucose tolerance
OT  - Prevalence
OT  - South Asians
OT  - Vitamin D
EDAT- 2020/03/28 06:00
MHDA- 2020/03/28 06:00
CRDT- 2020/03/28 06:00
PHST- 2020/03/28 06:00 [pubmed]
PHST- 2020/03/28 06:00 [medline]
PHST- 2020/03/28 06:00 [entrez]
AID - S0007114520001129 [pii]
AID - 10.1017/S0007114520001129 [doi]
PST - aheadofprint
SO  - Br J Nutr. 2020 Mar 26:1-8. doi: 10.1017/S0007114520001129.