PMID- 32215725
OWN - NLM
STAT- MEDLINE
DCOM- 20210413
LR  - 20210807
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 258
IP  - 7
DP  - 2020 Jul
TI  - Reproducibility and agreement of four anterior segment-optical coherence 
      tomography devices for anterior chamber angle measurements.
PG  - 1475-1481
LID - 10.1007/s00417-020-04648-1 [doi]
AB  - PURPOSE: To compare the reproducibility and agreement of anterior chamber angle 
      (ACA) parameters and metrics obtained by four different anterior segment-optical 
      coherence tomography (AS-OCT) devices. METHODS: In this prospective study, 30 
      eyes from 15 normal subjects underwent anterior segment angle scanning using the 
      Spectralis, Cirrus, and Optovue spectral domain optical coherence tomography 
      (SD-OCT), as well as the Visante time-domain optical coherence tomography 
      (TD-OCT). For each eye, the scan line was performed perpendicularly on the 
      inferior (270 degrees ) angle, and the inferior ACA image was acquired 2 times. 
      Inter-instrument and intra-instrument, as well as inter-observer and 
      intra-observer reproducibility of anterior chamber angle metrics, Schwalbe's line 
      (SL) to scleral spur (SS) distance (TM-Span), angle opening distance (AOD), and 
      trabecular iris space area (TISA) measurements, were evaluated by intraclass 
      correlation coefficients (ICCs) and Bland-Altman plots with limits of agreement 
      (LoA). RESULTS: For this cohort of 30 eyes of 15 normal subjects, the mean 
      TM-Span, AOD, and TISA were 0.966 +/- 0.198 mm, 0.750 +/- 0.205 mm, and 
      0.286 +/- 0.090 mm(2) from the Spectralis; 0.929 +/- 0.113 mm, 0.717 +/- 0.120 mm, and 
      0.267 +/- 0.095 mm(2) from the Cirrus; 0.923 +/- 0.191 mm, 0.683 +/- 0.161 mm, and 
      0.265 +/- 0.072 mm(2) from the Optovue; and 0.970 +/- 0.070 mm, 0.705 +/- 0.150 mm, and 
      0.279 +/- 0.065 mm(2) from the Visante. The intra-instrument (ICCs > 0.838), 
      intra-grader (ICCs > 0.910), and inter-grader (ICCs > 0.869) agreement were good. 
      Agreement between the four instruments was also good with ICCs from 0.901 to 
      0.967 for TM-Span, 0.887 to 0.941 for AOD, and 0.923 to 0.961 for TISA. 
      CONCLUSIONS: Consistent and reproducible ACA measurements could be obtained from 
      multiple AS-OCT devices including both SD- and TD-OCT instruments. These findings 
      have relevance when considering multiple imaging devices in future studies.
FAU - Pan, Xiaojing
AU  - Pan X
AD  - Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & 
      Shandong Academy of Medical Sciences, Qingdao, Shandong, People's Republic of 
      China.
FAU - Maram, Jyotsna
AU  - Maram J
AD  - Doheny Image Reading Center, Doheny Eye Institute, University of California Los 
      Angeles, Los Angeles, CA, USA.
FAU - Nittala, Muneeswar G
AU  - Nittala MG
AD  - Doheny Image Reading Center, Doheny Eye Institute, University of California Los 
      Angeles, Los Angeles, CA, USA.
FAU - Francis, Brian A
AU  - Francis BA
AD  - Doheny Image Reading Center, Doheny Eye Institute; Department of Ophthalmology, 
      David Geffen School of Medicine, University of California Los Angeles, Los 
      Angeles, CA, USA.
FAU - Chopra, Vikas
AU  - Chopra V
AD  - Doheny Image Reading Center, Doheny Eye Institute; Department of Ophthalmology, 
      David Geffen School of Medicine, University of California Los Angeles, Los 
      Angeles, CA, USA.
FAU - Sadda, Srinivas R
AU  - Sadda SR
AD  - Doheny Image Reading Center, Doheny Eye Institute; Department of Ophthalmology, 
      David Geffen School of Medicine, University of California Los Angeles, Los 
      Angeles, CA, USA. ssadda@doheny.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200326
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adult
MH  - Anterior Chamber/diagnostic imaging
MH  - Anterior Eye Segment/*diagnostic imaging
MH  - Equipment Design
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/*instrumentation
MH  - Young Adult
OTO - NOTNLM
OT  - AS-OCTs
OT  - Agreement
OT  - Anterior chamber angle
OT  - Metrics
OT  - Reproducibility
EDAT- 2020/03/28 06:00
MHDA- 2021/04/14 06:00
CRDT- 2020/03/28 06:00
PHST- 2019/11/05 00:00 [received]
PHST- 2020/03/13 00:00 [accepted]
PHST- 2020/03/07 00:00 [revised]
PHST- 2020/03/28 06:00 [pubmed]
PHST- 2021/04/14 06:00 [medline]
PHST- 2020/03/28 06:00 [entrez]
AID - 10.1007/s00417-020-04648-1 [pii]
AID - 10.1007/s00417-020-04648-1 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2020 Jul;258(7):1475-1481. doi: 
      10.1007/s00417-020-04648-1. Epub 2020 Mar 26.