PMID- 32215727 OWN - NLM STAT- MEDLINE DCOM- 20211209 LR - 20211214 IS - 1433-8491 (Electronic) IS - 0940-1334 (Print) IS - 0940-1334 (Linking) VI - 271 IP - 4 DP - 2021 Jun TI - Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia. PG - 783-798 LID - 10.1007/s00406-020-01119-w [doi] AB - Previous studies have demonstrated the efficacy of metacognitive training (MCT) in schizophrenia. However, the underlying mechanisms related to therapeutic effect of MCT remain unknown. The present study explored the treatment effects of MCT on brain regional neural activity using regional homogeneity (ReHo) and whether these regions' activities could predict individual treatment response in schizophrenia. Forty-one patients with schizophrenia and 20 healthy controls were scanned using resting-state functional magnetic resonance imaging. Patients were randomly divided into drug therapy (DT) and drug plus psychotherapy (DPP) groups. The DT group received only olanzapine treatment, whereas the DPP group received olanzapine and MCT for 8 weeks. The results revealed that ReHo in the right precuneus, left superior medial prefrontal cortex (MPFC), right parahippocampal gyrus and left rectus was significantly increased in the DPP group after 8 weeks of treatment. Patients in the DT group showed significantly increased ReHo in the left ventral MPFC/anterior cingulate cortex (ACC), left superior MPFC/middle frontal gyrus (MFG), left precuneus, right rectus and left MFG, and significantly decreased ReHo in the bilateral cerebellum VIII and left inferior occipital gyrus (IOG) after treatment. Support vector regression analyses showed that high ReHo levels at baseline in the right precuneus and left superior MPFC could predict symptomatic improvement of Positive and Negative Syndrome Scale (PANSS) after 8 weeks of DPP treatment. Moreover, high ReHo levels at baseline and alterations of ReHo in the left ventral MPFC/ACC could predict symptomatic improvement of PANSS after 8 weeks of DT treatment. This study suggests that MCT is associated with the modulation of ReHo in schizophrenia. ReHo in the right precuneus and left superior MPFC may predict individual therapeutic response for MCT in patients with schizophrenia. FAU - Shan, Xiaoxiao AU - Shan X AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. FAU - Liao, Rongyuan AU - Liao R AD - The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China. FAU - Ou, Yangpan AU - Ou Y AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. FAU - Pan, Pan AU - Pan P AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. FAU - Ding, Yudan AU - Ding Y AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. FAU - Liu, Feng AU - Liu F AD - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300000, China. FAU - Chen, Jindong AU - Chen J AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. FAU - Zhao, Jingping AU - Zhao J AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. FAU - Guo, Wenbin AU - Guo W AD - Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. guowenbin76@csu.edu.cn. AD - National Clinical Research Center on Mental Disorders, Changsha, 410011, Hunan, China. guowenbin76@csu.edu.cn. FAU - He, Yiqun AU - He Y AD - The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China. yiqunhe@163.com. LA - eng GR - 2016YFC1307100/National Key R&D Program of China/ GR - 2016YFC1306900/National Key R&D Program of China/ GR - 81571310, 81771447, and 81630033/National Natural Science Foundation of China/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20200325 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 RN - N7U69T4SZR (Olanzapine) SB - IM MH - Brain/diagnostic imaging MH - Brain Mapping MH - Humans MH - Magnetic Resonance Imaging MH - Olanzapine MH - *Schizophrenia/diagnostic imaging/drug therapy PMC - PMC8119286 OTO - NOTNLM OT - Metacognitive training OT - Olanzapine OT - Regional homogeneity OT - Schizophrenia OT - Support vector regression COIS- We declare that none of the authors holds any actual or potential conflict of interest for this study. EDAT- 2020/03/28 06:00 MHDA- 2021/12/15 06:00 PMCR- 2020/03/25 CRDT- 2020/03/28 06:00 PHST- 2019/07/30 00:00 [received] PHST- 2020/03/11 00:00 [accepted] PHST- 2020/03/28 06:00 [pubmed] PHST- 2021/12/15 06:00 [medline] PHST- 2020/03/28 06:00 [entrez] PHST- 2020/03/25 00:00 [pmc-release] AID - 10.1007/s00406-020-01119-w [pii] AID - 1119 [pii] AID - 10.1007/s00406-020-01119-w [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2021 Jun;271(4):783-798. doi: 10.1007/s00406-020-01119-w. Epub 2020 Mar 25.