PMID- 32216048
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210929
IS  - 1742-6723 (Electronic)
IS  - 1742-6723 (Linking)
VI  - 32
IP  - 5
DP  - 2020 Oct
TI  - Prospective study of the safety and effectiveness of droperidol in elderly 
      patients for pre-hospital acute behavioural disturbance.
PG  - 731-736
LID - 10.1111/1742-6723.13496 [doi]
AB  - OBJECTIVE: Acute behavioural disturbance in the elderly (>/=65 years) is a 
      significant issue for emergency medical services with increasing prevalence of 
      dementia and aging populations. We investigated the pre-hospital safety and 
      effectiveness of droperidol in the elderly with acute behavioural disturbance. 
      METHODS: This was a pre-hospital prospective observational 1-year study of 
      elderly patients with acute behavioural disturbance. The primary outcome was 
      proportion of adverse events (AEs) (airway intervention, oxygen saturation <90% 
      and/or respiratory rate <12/min, systolic blood pressure <90 mmHg, sedation 
      assessment tool score of -3 and dystonic reactions). Secondary outcomes included 
      time to sedation, additional sedation, proportion with successful sedation. 
      RESULTS: There were 149 patients (males 78 [52%], median age 78 years; 
      65-101 years) presenting on 162 occasions. Dementia was the commonest cause 
      (107/164 [65%]) of acute behavioural disturbance. There were six AEs in five 
      patients (5/162 [3%]; 95% confidence interval 1-7). Three had hypotension, one 
      with associated hypoxia (80%); and two had respiratory AEs (respiratory rate, 
      10/min [no hypoxia] and hypoxia [88%] which required oxygen). Median time to 
      sedation was 19 min (interquartile range 12-29 min). Additional sedation was 
      given in 2/162 patients during ambulance transfer and 16/162 within an hour of 
      hospital arrival; 24/162 (15%) failed to sedate in the ambulance; 16 subsequently 
      settled in ED and 8/24 received additional sedation. Of 162, 123 (76%) patients 
      successfully sedated, without AEs or additional sedation. Of 162, 114 (70%) 
      patients received 5 mg, 46 (29%) received two doses of 5 mg and two patients (1%) 
      received three doses. CONCLUSIONS: Droperidol appeared to be safe and effective 
      for pre-hospital sedation of acute behavioural disturbance in elderly patients.
CI  - (c) 2020 Australasian College for Emergency Medicine.
FAU - Page, Colin B
AU  - Page CB
AD  - Clinical Toxicology Research Group, The University of Newcastle, Newcastle, New 
      South Wales, Australia.
AD  - Faculty of Medicine, The University of Queensland, Brisbane, Queensland, 
      Australia.
AD  - Clincial Toxicology Unit, Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
FAU - Parker, Lachlan E
AU  - Parker LE
AD  - Queensland Ambulance Service, Brisbane, Queensland, Australia.
FAU - Rashford, Stephen J
AU  - Rashford SJ
AD  - Queensland Ambulance Service, Brisbane, Queensland, Australia.
FAU - Kulawickrama, Sanjeewa
AU  - Kulawickrama S
AD  - Department of Emergency Medicine, Gold Coast University Hospital, Gold Coast, 
      Queensland, Australia.
AD  - Faculty of Medicine, Bond University, Gold Coast, Queensland, Australia.
FAU - Isoardi, Katherine Z
AU  - Isoardi KZ
AUID- ORCID: 0000-0002-1176-7923
AD  - Faculty of Medicine, The University of Queensland, Brisbane, Queensland, 
      Australia.
AD  - Clincial Toxicology Unit, Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Queensland Ambulance Service, Brisbane, Queensland, Australia.
FAU - Isbister, Geoffrey K
AU  - Isbister GK
AUID- ORCID: 0000-0003-1519-7419
AD  - Clinical Toxicology Research Group, The University of Newcastle, Newcastle, New 
      South Wales, Australia.
AD  - Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, 
      Newcastle, New South Wales, Australia.
LA  - eng
GR  - 1061041/National Health and Medical Research Council/International
GR  - Queensland Emergency Medicine Research Foundation/International
GR  - Emergency Medicine Foundation Research Fellowship/International
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200326
PL  - Australia
TA  - Emerg Med Australas
JT  - Emergency medicine Australasia : EMA
JID - 101199824
RN  - O9U0F09D5X (Droperidol)
SB  - IM
CIN - Emerg Med Australas. 2021 Apr;33(2):390-391. PMID: 33561901
MH  - Aged
MH  - Conscious Sedation
MH  - *Droperidol/therapeutic use
MH  - *Emergency Medical Services
MH  - Emergency Service, Hospital
MH  - Hospitals
MH  - Humans
MH  - Prospective Studies
OTO - NOTNLM
OT  - acute behavioural disturbance
OT  - chemical sedation
OT  - elderly
OT  - pre-hospital
EDAT- 2020/03/28 06:00
MHDA- 2021/07/20 06:00
CRDT- 2020/03/28 06:00
PHST- 2019/10/24 00:00 [received]
PHST- 2020/02/06 00:00 [revised]
PHST- 2020/02/19 00:00 [accepted]
PHST- 2020/03/28 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2020/03/28 06:00 [entrez]
AID - 10.1111/1742-6723.13496 [doi]
PST - ppublish
SO  - Emerg Med Australas. 2020 Oct;32(5):731-736. doi: 10.1111/1742-6723.13496. Epub 
      2020 Mar 26.