PMID- 32217287 OWN - NLM STAT- MEDLINE DCOM- 20201021 LR - 20201021 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 164 DP - 2020 Apr TI - Pulmonary nodular and cystic light chain deposition disease: A retrospective review of 10 cases. PG - 105896 LID - S0954-6111(20)30036-6 [pii] LID - 10.1016/j.rmed.2020.105896 [doi] AB - INTRODUCTION: Light chain deposition disease (LCDD) rarely involves the lungs. We report clinical and radiologic findings of pulmonary LCDD. METHODS: We retrospectively identified patients with biopsy-proven pulmonary LCDD seen at Mayo Clinic (Rochester, Minnesota) from January 1997 through December 2018. Demographic, clinical, and imaging features were analyzed. RESULTS: We identified 10 patients with pulmonary LCDD (median age at diagnosis, 55 years; range, 39-77 years). Eight patients were women and 7 were never-smokers. Dyspnea (n = 3) and chest pain (n = 3) were the most common respiratory symptoms. Associated conditions included Sjogren syndrome (n = 6), sarcoidosis (n = 1), and limited scleroderma (n = 1). Eight patients had mucosa-associated lymphoid tissue (MALT) lymphoma. Among the 9 patients with chest computed tomography (CT) images, 8 (89%) had cysts. Cysts were predominantly distributed in the lower lung and were round or oval. All patients had multiple cysts (5 patients had 1-5 cysts, 3 had >20 cysts). The median diameter of the largest cyst was 18 mm (range, 5-68 mm). All 9 patients had solid nodules (3 had >10 nodules). Five patients had subsolid nodules. The median diameter of the largest solid nodules was 13 mm (range, 6-26 mm). Positron emission tomography-CT images were available for 8 patients. The median maximum standardized uptake value of the most avid pulmonary nodule was 2.2 (range, 1.9-6.0). Two patients died during a median follow-up of 2.3 years (range, 0.5-9.9 years). CONCLUSIONS: Pulmonary LCDD is characterized by cysts and nodules. The disease is associated with MALT lymphoma, especially in the setting of Sjogren syndrome. CI - Copyright (c) 2020. Published by Elsevier Ltd. FAU - Baqir, Misbah AU - Baqir M AD - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: baqir.misbah@mayo.edu. FAU - Moua, Teng AU - Moua T AD - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. FAU - White, Darin AU - White D AD - Department of Radiology, Mayo Clinic, Rochester, MN, USA. FAU - Yi, Eunhee S AU - Yi ES AD - Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA. FAU - Ryu, Jay H AU - Ryu JH AD - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. LA - eng PT - Journal Article DEP - 20200214 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 RN - 0 (Immunoglobulin Light Chains) SB - IM MH - Adult MH - Aged MH - Comorbidity MH - Cysts/epidemiology MH - Female MH - Humans MH - Immunoglobulin Light Chains/*metabolism MH - Lung Diseases/epidemiology MH - Lymphoma, B-Cell, Marginal Zone/complications MH - Male MH - Middle Aged MH - Multiple Pulmonary Nodules/diagnostic imaging/epidemiology/*metabolism/pathology MH - Retrospective Studies MH - Sarcoidosis/epidemiology MH - Scleroderma, Limited/epidemiology MH - Sjogren's Syndrome/epidemiology OTO - NOTNLM OT - Cysts OT - Nodules OT - Pulmonary light chain deposition disease COIS- Declaration of competing interest None of the authors have any conflicts of interest to disclose. EDAT- 2020/03/29 06:00 MHDA- 2020/10/22 06:00 CRDT- 2020/03/29 06:00 PHST- 2019/10/02 00:00 [received] PHST- 2020/02/03 00:00 [revised] PHST- 2020/02/05 00:00 [accepted] PHST- 2020/03/29 06:00 [entrez] PHST- 2020/03/29 06:00 [pubmed] PHST- 2020/10/22 06:00 [medline] AID - S0954-6111(20)30036-6 [pii] AID - 10.1016/j.rmed.2020.105896 [doi] PST - ppublish SO - Respir Med. 2020 Apr;164:105896. doi: 10.1016/j.rmed.2020.105896. Epub 2020 Feb 14.