PMID- 32218307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 9
IP  - 4
DP  - 2020 Mar 25
TI  - Corylin Inhibits Vascular Cell Inflammation, Proliferation and Migration and 
      Reduces Atherosclerosis in ApoE-Deficient Mice.
LID - 10.3390/antiox9040275 [doi]
LID - 275
AB  - Atherosclerosis is a complex disease that includes several events, including 
      reactive oxygen species (ROS) stress, inflammation, endothelial dysfunction, 
      lipid deposition, and vascular smooth muscle cell (VSMC) proliferation and 
      migration, which result in atherosclerotic plaque formation. Corylin, a flavonoid 
      compound, is known to exhibit antioxidative, anti-inflammatory and 
      antiproliferative effects. However, it remains unknown whether corylin could 
      modulate atherogenesis. Here, we identified the anti-inflammatory effect of 
      corylin in tumor necrosis factor-alpha (TNF-alpha)-induced vascular cells. In human 
      umbilical vein endothelial cells (HUVECs), corylin suppressed TNF-alpha-induced 
      monocyte adhesion to the HUVECs and transmigration by downregulating the 
      ROS/JNK/nuclear factor-kappa beta (NF-kappaB) p65 pathway. In VSMCs, corylin 
      inhibited TNF-alpha-induced monocyte adhesion by suppressing ROS production, 
      mitogen-activated protein kinase (MAPK) phosphorylation and NF-kappaB p65 
      translocation. In platelet-derived growth factor-BB (PDGF-BB)-induced VSMCs, 
      corylin inhibited PDGF-BB-induced VSMC proliferation and migration through 
      regulating the mammalian target of rapamycin (mTOR)/dynamin-1-like protein 1 
      (Drp1) signaling cascade. In addition, corylin treatment not only attenuated 
      atherosclerotic lesions, ROS production, vascular cell adhesion protein-1 
      (VCAM-1) expression, monocyte adhesion and VSMC proliferation in apolipoprotein E 
      (ApoE)-deficient mice but also inhibited neointimal hyperplasia in 
      endothelial-denuded mice. Thus, corylin may be a potential prevention and 
      treatment for atherosclerosis.
FAU - Chen, Chin-Chuan
AU  - Chen CC
AD  - Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, 
      Taiwan.
AD  - Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung 
      University, Taoyuan 33302, Taiwan.
AD  - Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
FAU - Li, Hung-Yuan
AU  - Li HY
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      10002, Taiwan.
FAU - Leu, Yann-Lii
AU  - Leu YL
AD  - Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, 
      Taiwan.
AD  - Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung 
      University, Taoyuan 33302, Taiwan.
AD  - Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan 
      33305, Taiwan.
FAU - Chen, Yu-Ju
AU  - Chen YJ
AD  - Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, 
      Taiwan.
FAU - Wang, Chia-Jen
AU  - Wang CJ
AD  - Cell Therapy Center, Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
FAU - Wang, Shu-Huei
AU  - Wang SH
AD  - Department of Anatomy and Cell Biology, College of Medicine, National Taiwan 
      University, Taipei 10051, Taiwan.
LA  - eng
GR  - NSC 108-2320-B-002 -045/National Science Council/
PT  - Journal Article
DEP - 20200325
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7222202
OTO - NOTNLM
OT  - ROS
OT  - atherosclerosis
OT  - corylin
OT  - inflammation
OT  - mitofission
COIS- The authors declare no conflict of interest.
EDAT- 2020/03/29 06:00
MHDA- 2020/03/29 06:01
PMCR- 2020/03/25
CRDT- 2020/03/29 06:00
PHST- 2020/02/11 00:00 [received]
PHST- 2020/03/11 00:00 [revised]
PHST- 2020/03/23 00:00 [accepted]
PHST- 2020/03/29 06:00 [entrez]
PHST- 2020/03/29 06:00 [pubmed]
PHST- 2020/03/29 06:01 [medline]
PHST- 2020/03/25 00:00 [pmc-release]
AID - antiox9040275 [pii]
AID - antioxidants-09-00275 [pii]
AID - 10.3390/antiox9040275 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2020 Mar 25;9(4):275. doi: 10.3390/antiox9040275.